This product is a research use only (RUO) item and is not specifically recommended for validating hemolysis testing on a chemistry analyzer.
H7379
Hemoglobin human
lyophilized powder
Synonyma:
Hb
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| Vám/Skladová položka | Dostupnost | Cena |
|---|---|---|
1 g | Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti. | 2 570,00 Kč |
5 g | Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti. | 7 900,00 Kč |
10 g | Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti. | 12 100,00 Kč |
O této položce
Form:
lyophilized powder
Biological source:
human
2 570,00 Kč
Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.
Technický servis
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Dovolte nám, abychom vám pomohlibiological source
human
Quality Segment
form
lyophilized powder
technique(s)
enzyme immunoassay: suitable
impurities
HIV and hepatitis B antigen, tested negative
solubility
H2O: soluble 20 mg/mL
storage temp.
2-8°C
Gene Information
human ... HBA1(3039), HBA2(3040), HBB(3043), HBD(3045), HBE1(3046), HBG1(3047), HBG2(3048), HBQ1(3049), HBZ(3050)
General description
Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.
Application
Biochem/physiol Actions
Oxygen transporter, NO scavenger
The Fe2+/Fe3+ balance is a physiological indicator of blood oxygenation. Deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to NO, a vasodilator which enhances blood flow to oxygen-deprived tissues.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Since native hemoglobin is readily oxidized in air, these preparations may be predominantly methemoglobin.
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Tato položka | |||
|---|---|---|---|
| technique(s) enzyme immunoassay: suitable | technique(s) MALDI-TOF: suitable | technique(s) activity assay: suitable | technique(s) - |
| biological source human | biological source bovine blood | biological source bovine blood | biological source bovine blood |
| form lyophilized powder | form lyophilized powder | form substrate powder | form powder |
| Gene Information human ... HBA1(3039), HBA2(3040), HBB(3043), HBD(3045), HBE1(3046), HBG1(3047), HBG2(3048), HBQ1(3049), HBZ(3050) | Gene Information cow ... HBA1(281221), HBB(280813), HBE2(513240), HBE4(513108), HBG(511735), alpha globin(512439) | Gene Information cow ... HBA1(281221), HBB(280813), HBE2(513240), HBE4(513108), HBG(511735), alpha globin(512439) | Gene Information cow ... HBA1(281221), HBB(280813), HBE2(513240), HBE4(513108), HBG(511735), alpha globin(512439) |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility H2O: soluble 20 mg/mL | solubility - | solubility H2O: soluble 20 mg/mL | solubility - |
Skladovací třída
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Can I use this product to validate hemolysis testing on chemistry analyzer.
1 answer-
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Would H7379 Hemoglobin Human has population of glycated hb as well? If yes, what level?
1 answer-
MilliporeSigma, on product H7379, does not perform any sort of characterization as to whether any particular subfraction of H7379 is glycated. H7379 is a general hemoglobin product and not any single one isoform.
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I would like to know if the product loses stability if it is kept in a freezer at -20, since the recommended temperature is between 2 and 8 degrees Celsius.
1 answer-
The stability of the hemoglobin powder at -20°C has not been evaluated. However, storage of the powder at freezer temperature is not expected to cause degradation. Please see the link below to review additional information available in the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/837/353/h7379pis.pdfHelpful?
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What are the recommendations for long-term storage once it is solubilized? Is it OK to make single-use aliquots for -80°C?
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The stability of this material in solution has not been evaluated. However, other commercially available hemoglobin solutions, intended for use as microbiological medium supplements, are reportedly stable for more than 1 year when stored at 2-8°C.
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Can it be reconstituted to a final concentration of 17 g/dL?
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A concentration of 17 g/dL exceeds the solubility recommendation. Each batch released is tested and guaranteed to dissolve in deionized water at up to 20 mg/mL.
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What is this product H7379 lyophilized in? When I reconstitute in water should I account for sucrose or other buffer components?
1 answer-
The protein was dialyzed against deionized water before the lyophilization step.
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I noticed that the solubility of H7379 in H2O is only 20 mg/mL. We are looking for Hb solution with concentration from 10 to 20 g/dL. Could you kindly advise whether the power can have higher solubility in any other liquid?
1 answer-
This product is tested for solubility at 20 mg/mL during quality control testing in water. Testing in other liquids for higher solubility has not been performed.
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What is the standard of this reagent?
1 answer-
This product contains a dark red to red-brown human hemoglobin powder. The standards specified in the Certificate of Analysis include low water content (≤ 15%) and an iron level within 0.25–0.35%. Tests for hepatitis B surface antigen, hepatitis C virus, and human immunodeficiency virus are negative.
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This product lists HBG in the Gene list. Can you confirm that Hb gamma is present in this product?
1 answer-
The specification for this product does not require testing for Hb gamma. Information found under the Properties or Description sections of the Product Detail page is generally sourced from the literature. Below is the link to the Specification Sheet for reference: https://www.sigmaaldrich.com/specification-sheets/904/492/H7379-BULK________SIGMA____.pdf
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Hi, what is the bulk density of this product ?
1 answer-
Unfortunately, the bulk density of this product is not determined.
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