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C3788

Chondroitin sulfate B sodium salt

from Porcine intestinal mucosa, ≥90%, lyophilized powder

Synonyma:

β-Heparin, Dermatan sulfate sodium salt

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Vybrat velikost

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Velikost baleníSkladová položkaDostupnostCena
25 mg
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2 630,00 Kč
100 mg
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7 990,00 Kč

O této položce

Číslo CAS:
54328-33-5
UNSPSC Code:
12352201
NACRES:
NA.25
MDL number:
MFCD00151683

2 630,00 Kč

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biological source

Porcine intestinal mucosa

Quality Level

200

assay

≥90%

form

lyophilized powder

impurities

≤20% water (Karl Fischer)

color

white

solubility

H2O: 5 mg/mL, clear, colorless

cation traces

Na: 7.0-11.5%

storage temp.

2-8°C

General description

Chondroitin, a glucosaminoglycan (GAG), is a polysaccharide chain of alternating units of N-acetylgalactosamine (GalNAc) and glucuronic acid (GlcA) that can be sulfated on the either or both GalNAc and GlcA units. Chondroitin and its sulfates are frequently attached to proteins to form proteoglycans. Chondroitin sulfate B (Dermatam sulfate) is a component of proteoglycans such as decorin, biglycan and versican. Chondroitin sulfate B is used to study β peptide (1-42) cytotoxicity.

Application

Chondroitin sulfate B may be used to study its roles as a biomolecule receptor, mediator of cell signaling and cell binding molecule. It may be used to compare its properties to those of chondroitin sulfate A and chondroitin sulfate C. Chondroitin sulfate B is used to study β peptide(1-42) cytotoxicity.

Biochem/physiol Actions

As a large, negatively charged, hydrophilic molecule that is too inflexible to fold into a compact globular structure, chondroitin sulfate molecules form porous hydrated gels, providing mechanical support to tissue and allowing rapid diffusion of water-soluble molecules and migration of cells.

Preparation Note

This product is soluble in water at 100 mg/mL.

Other Notes

Chondroitin Sulfate B is an acidic mucopolysaccharide found in cartilage, skin, cornea, and umbilical cord. It is composed of alternating N-acetylgalactosamine, L-iduronic acid, and sulfate residues in equimolar quantities where carbon 4 of the N-acetylgalactosamines is sulfated.
To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Disclaimer

Store this product at 2-8°C.

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Tato položka
C6737C3920PHR1786
Chondroitin sulfate B sodium salt from Porcine intestinal mucosa, ≥90%, lyophilized powder

Sigma-Aldrich

C3788

Chondroitin sulfate B sodium salt

Sigma-Aldrich

Sigma-Aldrich

C6737

Chondroitin sulfate sodium salt from bovine cartilage

Chondroitin disaccharide Δdi-0S sodium salt ≥95% (HPLC)

Sigma-Aldrich

C3920

Chondroitin disaccharide Δdi-0S sodium salt

Chondroitin Sulfate Sodium Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1786

Chondroitin Sulfate Sodium

assay

≥90%

assay

98-102% (CPC, titration)

assay

≥95% (HPLC)

assay

-

biological source

Porcine intestinal mucosa

biological source

bovine cartilage

biological source

-

biological source

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

solubility

H2O: 5 mg/mL, clear, colorless

solubility

H2O: soluble 50 mg/mL, clear to hazy, colorless to faintly yellow

solubility

H2O: soluble 10 mg/mL, clear, colorless

solubility

-

form

lyophilized powder

form

powder

form

powder

form

solid

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-30°C

Skladovací třída

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Osvědčení o analýze (COA)

Lot/Batch Number
0000522167
0000522167
0000523426
0000523426
0000523427

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Potřebujete-li konkrétní verzi, můžete vyhledat daný certifikát podle čísla dávky nebo čísla šarže.

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Sortimentní položky

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Glykosaminoglykany a proteoglykany

Zjistěte více o glykosaminoglykanech a proteoglykanech, včetně struktury glykosaminoglykanů (GAG), různých typů GAG a jejich funkcí.

Glycosaminoglycans and Proteoglycans

Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.

Sylvia Gruber et al.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 194(7), 675-685 (2018-03-03)
Oral mucositis is a frequent, dose-limiting side effect of radio(chemo)therapy of head-and-neck malignancies. The epithelial radiation response is based on multiple tissue changes, which could offer targets for a biologically tailored treatment. The potential of dermatan sulfate (DS) to modulate radiation-induced oral
Ana M Saraiva et al.
Macromolecular bioscience, 10(10), 1152-1163 (2010-05-19)
The amyloid-β peptide (Aβ) plays a central role in the mechanism of Alzheimer's disease, being the main constituent of the plaque deposits found in AD brains. Aβ amyloid formation and deposition are due to a conformational switching to a β-enriched
Sylvia Gruber et al.
International journal of molecular sciences, 19(6) (2018-06-09)
Oral mucositis is the most frequently occurring early side effect of head-and-neck cancer radiotherapy. Systemic dermatan sulfate (DS) treatment revealed a significant radioprotective potential in a preclinical model of oral mucositis. This study was initiated to elucidate the mechanistic effects
Zobrazit všechny související dokumenty

Globální číslo obchodní položky

Skladová položkaGTIN
C3788-100MG04061833486405
C3788-25MG04061833486412

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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