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B1793

Bafilomycin A1

Name: Bafilomycin A1
Brand: SIGMA
Price: 3780 CZK

from Streptomyces griseus, ≥90% (HPLC), film, V-ATPase inhibitor

Bafilomycin A1 from Streptomyces griseus

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Velikost balení	Skladová položka	Dostupnost	Cena
2 μg		Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.	3 780,00 Kč
10 μg		Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.	11 100,00 Kč

O této položce

Empirický vzorec (Hillův zápis):

C₃₅H₅₈O₉

Číslo CAS:

88899-55-2

Molekulová hmotnost:

622.83

UNSPSC Code:

12352200

PubChem Substance ID:

24891613

NACRES:

NA.77

Beilstein/REAXYS Number:

4730700

MDL number:

MFCD06795130

Assay:

≥90% (HPLC)

Form:

film

Quality level:

300

3 780,00 Kč

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Vlastnosti

Název produktu

Bafilomycin A1 from Streptomyces griseus, ≥90% (HPLC)

Quality Level

300

assay

≥90% (HPLC)

form

film

antibiotic activity spectrum

fungi

mode of action

DNA synthesis | interferes, enzyme | inhibits

storage temp.

−20°C

SMILES string

CO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(C)\C=C(OC)C(=O)OC1[C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)[C@H](O2)C(C)C

InChI

1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1

InChI key

XDHNQDDQEHDUTM-JQWOJBOSSA-N

Popis

General description

Chemical structure: macrolide

Application

Bafilomycin A1 has been used:

as an autophagy inhibitor to study its effects on hepatic steatosis in human hepatocytes
as a vacuolar-type H⁺ -ATPase inhibitor to study its effects on the cell viability, percentage of PI-positive cells, and glucose-stimulated insulin secretion (GSIS) in mice INS-1 cells[1]
as a vacuolar-type H⁺ -ATPase inhibitor to study its effects on tau degradation in human SH-SY5Y cells[2]

Biochem/physiol Actions

A specific inhibitor of vacuolar type H⁺-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.

Bafilomycin A1 inhibits autophagosome-lysosome fusion and autolysosome acidification, the steps involved in the autophagic process that is required for maintaining functional autophagic flux and cellular homeostasis.[3]

Specific inhibitor of vacuolar type H⁺-ATPase (V-ATPase).

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

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Tato položka	R0395	O4876	46745
Sigma-Aldrich B1793 Bafilomycin A1 from Streptomyces griseus	Sigma-Aldrich R0395 Rapamycin from Streptomyces hygroscopicus	Sigma-Aldrich O4876 Oligomycin from Streptomyces diastatochromogenes	Supelco 46745 Spiramycin from Streptomyces sp.
assay ≥90% (HPLC)	assay ≥95% (HPLC)	assay ≥90% total oligomycins basis (HPLC)	assay -
form film	form powder	form powder	form -
Quality Level 300	Quality Level 300	Quality Level 200	Quality Level 200
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C
antibiotic activity spectrum fungi	antibiotic activity spectrum fungi, yeast	antibiotic activity spectrum fungi	antibiotic activity spectrum Gram-positive bacteria
mode of action DNA synthesis \| interferes, enzyme \| inhibits	mode of action enzyme \| inhibits, protein synthesis \| interferes	mode of action enzyme \| inhibits	mode of action protein synthesis \| interferes

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Skladovací třída

11 - Combustible Solids

wgk

WGK 3

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dust mask type N95 (US), Eyeshields, Gloves

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Sortimentní položky

Autophagy in Cancer Promotes Therapeutic Resistance

We presents an article on Autophagy in Cancer Promotes Therapeutic Resistance

Související obsah

Autophagy in Cancer Promotes Therapeutic Resistance

Autophagy in Cancer

ERK-dependent mTOR pathway is involved in berberine-induced autophagy in hepatic steatosis

He Q, et al.

Journal of Molecular Endocrinology, 57(4) (2016)

Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle.

Jens Niewoehner et al.

Neuron, 81(1), 49-60 (2014-01-15)

Although biotherapeutics have vast potential for treating brain disorders, their use has been limited due to low exposure across the blood-brain barrier (BBB). We report that by manipulating the binding mode of an antibody fragment to the transferrin receptor (TfR)

The cytotoxic action of diphtheria toxin and its degradation in intact Vero cells are inhibited by bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase.

T Umata et al.

The Journal of biological chemistry, 265(35), 21940-21945 (1990-12-15)

The role of vacuolar-type H(+)-ATPase (V-ATPase) in the cytotoxic action of diphtheria toxin (DT) was studied by using bafilomycin A1, a specific inhibitor of V-ATPase. Studies with acridine orange showed that the acidification of intracellular acidic compartments was inhibited strongly

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Globální číslo obchodní položky

Skladová položka	GTIN
B1793-2UG	04061838443809
B1793-10UG	04061838443793