A2504

6-Aminocaproic acid

≥99% (titration), powder

• Synonyma: ε-Aminocaproic acid, 6-Aminohexanoic acid, EACA
• Lineární vzorec: H₂N(CH₂)₅CO₂H
• Číslo CAS: 60-32-2
• Molekulová hmotnost: 131.17
• UNSPSC Code: 12352202
• NACRES: NA.77
• PubChem Substance ID: 24890662
• EC Number: 200-469-3
• Beilstein/REAXYS Number: 906872
• MDL number: MFCD00008238
• Assay: ≥99% (titration)
• Form: powder

Vlastnosti

• biological source: synthetic
• Quality Level: 300
• assay: ≥99% (titration)
• form: powder
• technique(s): cell culture | mammalian: suitable
• color: white
• mp: 207-209 °C (dec.) (lit.)
• solubility: H₂O: 50 mg/mL
• SMILES string: NCCCCCC(O)=O
• InChI: 1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
• InChI key: SLXKOJJOQWFEFD-UHFFFAOYSA-N
• Gene Information: human ... PLAT(5327), PLG(5340) ; rat ... Ppm1a(24666)

Popis

Application

EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl₂, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.

Biochem/physiol Actions

EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo­xy­peptidase, plasmin, and plasminogen activator.

Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis.

Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• flash_point_f: 404.6 - 408.2 °F
• flash_point_c: 207 - 209 °C
• ppe: dust mask type N95 (US), Eyeshields, Gloves