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27602

Caffeine

Name: Caffeine
Brand: SIAL
Price: 3480 CZK

anhydrous, tested according to Ph. Eur.

Synonyma:

Coffeinum, 1,3,7-Trimethylxanthine

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Velikost balení	Skladová položka	Dostupnost	Cena
250 g		Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.	3 480,00 Kč

O této položce

Empirický vzorec (Hillův zápis):

C₈H₁₀N₄O₂

Číslo CAS:

58-08-2

Molekulová hmotnost:

194.19

UNSPSC Code:

12352210

NACRES:

NA.21

PubChem Substance ID:

329753004

EC Number:

200-362-1

Beilstein/REAXYS Number:

17705

MDL number:

MFCD00005758

Grade:

anhydrous

Agency:

tested according to Ph. Eur.

3 480,00 Kč

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Vlastnosti

grade

anhydrous

Quality Level

100

agency

tested according to Ph. Eur.

form

powder

mp

234-236.5 °C (lit.)

solubility

H₂O: soluble 18.7 g/L at 16 °C

application(s)

environmental

SMILES string

CN1C(=O)N(C)c2ncn(C)c2C1=O

InChI

1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

InChI key

RYYVLZVUVIJVGH-UHFFFAOYSA-N

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE4B(5142)
mouse ... Adora2b(11541)
rat ... Adora1(29290), Adora2a(25369)

Popis

Application

Caffeine has been used as a radiosensitizing agent utilized for studying its impact in inhibiting the catalytic activity of ATM and ATR Kinase.[1] CTGF is an important modulator protein of fibrogenic TGF-β. Hence, this product has also been used for examining the caffeine-dependent regulation of CTGF expression in rat hepatocytes.[2]

Biochem/physiol Actions

Caffeine is a central nervous system stimulant, adenosine receptor antagonist as well as adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. It stimulates the sarcoplasmic reticulum (SR) Ca²⁺-release channel which facilitates the excitation-contraction coupling in cardiac muscle.[3] It has also been reported to affect cellular calcium levels, releasing calcium from intracellular stores. Caffeine overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.[4]

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Tato položka	C7731	C1778	W222455
Sigma-Aldrich 27602 Caffeine	Sigma-Aldrich C7731 Caffeine	Sigma-Aldrich C1778 Caffeine	Sigma-Aldrich W222455 Caffeine
grade anhydrous	grade anhydrous	grade -	grade FG, Halal, Kosher, anhydrous, natural
agency tested according to Ph. Eur.	agency USP/NF, meets USP testing specifications	agency -	agency -
mp 234-236.5 °C (lit.)	mp 234-236.5 °C (lit.)	mp 234-236.5 °C (lit.)	mp 234-236.5 °C (lit.)
application(s) environmental	application(s) -	application(s) -	application(s) flavors and fragrances
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 300
Gene Information human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE4B(5142) mouse ... Adora2b(11541) rat ... Adora1(29290), Adora2a(25369)	Gene Information human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE4B(5142) mouse ... Adora2b(11541) rat ... Adora1(29290), Adora2a(25369)	Gene Information human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE4B(5142) mouse ... Adora2b(11541) rat ... Adora1(29290), Adora2a(25369)	Gene Information -

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Skladovací třída

11 - Combustible Solids

wgk

WGK 1

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

flash_point_f

Not applicable

flash_point_c

Not applicable

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Lot/Batch Number

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Molecular mechanisms of DNA repair inhibition by caffeine.

C P Selby et al.

Proceedings of the National Academy of Sciences of the United States of America, 87(9), 3522-3525 (1990-05-01)

Caffeine potentiates the mutagenic and lethal effects of genotoxic agents. It is thought that this is due, at least in some organisms, to inhibition of DNA repair. However, direct evidence for inhibition of repair enzymes has been lacking. Using purified

In Vitro-In Silico Modeling of Caffeine and Diclofenac Permeation in Static and Fluidic Systems with a 16HBE Lung Cell Barrier.

Lukas Kovar et al.

Pharmaceuticals (Basel, Switzerland), 15(2) (2022-02-27)

Static in vitro permeation experiments are commonly used to gain insights into the permeation properties of drug substances but exhibit limitations due to missing physiologic cell stimuli. Thus, fluidic systems integrating stimuli, such as physicochemical fluxes, have been developed. However

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

J N Sarkaria et al.

Cancer research, 59(17), 4375-4382 (1999-09-15)

Caffeine exposure sensitizes tumor cells to ionizing radiation and other genotoxic agents. The radiosensitizing effects of caffeine are associated with the disruption of multiple DNA damage-responsive cell cycle checkpoints. The similarity of these checkpoint defects to those seen in ataxia-telangiectasia

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Globální číslo obchodní položky

Skladová položka	GTIN
27602-250G	04061826185421

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