T9531

D-(+)-Trehalose dihydrate

≥99% (HPLC), from Saccharomyces cerevisiae

• Synonyma: Trehalose dihydrate, α,α-Trehalose, α-D-Glucopyranosyl-α-D-glucopyranoside
• Empirický vzorec (Hillův zápis): C₁₂H₂₂O₁₁ · 2H₂O
• Číslo CAS: 6138-23-4
• Molekulová hmotnost: 378.33
• UNSPSC Code: 12352201
• NACRES: NA.25
• PubChem Substance ID: 57654693
• EC Number: 202-739-6
• Beilstein/REAXYS Number: 5322018
• MDL number: MFCD00071594

Vlastnosti

• biological source: Saccharomyces cerevisiae
• Quality Level: 300
• assay: ≥99% (HPLC)
• form: powder
• optical activity: [α]20/D 174 to 182 °, c = 7% (w/v) in water
• technique(s): HPLC: suitable, PCR: suitable, cell based assay: suitable, cryopreservation: suitable
• impurities: ≤5.0% EtOH, <20 ppm Trace metals
• color: white
• mp: 97-99 °C
• solubility: water: 50 mg/mL, clear, colorless
• application(s): advanced drug delivery; advanced drug delivery; agriculture; cell analysis; life science and biopharma; sample preparation
• storage temp.: room temp
• SMILES string: [H]O[H].[H]O[H].OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1
• InChI key: DPVHGFAJLZWDOC-PVXXTIHASA-N

Popis

General description

Trehalose, also known as mycose or tremalose, is a nonreducing disaccharide of glucose commonly found in fungi, bacteria, and invertebrates. Its presence in these organisms highlights its significance in various biological processes and potential applications in biochemical research and cell culture studies.

Application

D-(+)-Trehalose dihydrate has been used:

• as a transcription factor EB (TFEB) to study its effects on an autophagy-lysosomal system in human silicosis alveolar macrophages[1]
• as stabilizing excipient in spray-dried protein formulations[2]
• as a cryoprotectant to study its effects on mouse testicular cell suspensions[3]

Biochem/physiol Actions

D-(+)-Trehalose shows anti-desiccant and cryopreservative activities. It acts as an osmolyte, and stress protectant and helps in the storage and transport of carbon. Trehalose is involved in the food, cosmetic, and pharmaceutical industries. It plays a vital role in the survival of certain insects and plants known as anhydrobionts during harsh environments such as high rates of dehydration.

Preparation Note

Prepared by ion exchange chromatography.

Analysis Note

Reduced metal ion content.

Other Notes

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Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)