T1783

Tobramycin sulfate salt

aminoglycoside antibiotic

• Synonyma: Nebramycin Factor 6 sulfate
• Empirický vzorec (Hillův zápis): C₁₈H₃₇N₅O₉ · xH₂SO₄
• Molekulová hmotnost: 467.51 (free base basis)
• NACRES: NA.85
• PubChem Substance ID: 329826686
• UNSPSC Code: 51281677
• MDL number: MFCD00133864

Vlastnosti

• biological source: Streptomyces tenebrarius
• Quality Segment: 200
• form: powder
• potency: 634-739 μg per mg
• storage condition: (Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.)
• color: white to off-white
• solubility: H₂O: soluble 50 mg/mL
• antibiotic activity spectrum: Gram-negative bacteria
• mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
• InChI: 1S/C18H37N5O9.H2O4S/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18;1-5(2,3)4/h5-18,24-28H,1-4,19-23H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+;/m0./s1
• InChI key: ZEUUPKVZFKBXPW-TWDWGCDDSA-N

Popis

General description

Chemical structure: aminoglycoside

Application

Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is not effective against Enterococci. It is used to inhibit bacterial protein synthesis at the level of 30S (16S rRNA) and 70S ribosomal complex assembly. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis and other soft-tissue infections. It is a potential therapy for sinus infections[1]. Product T1783 has been used to study antibiotic resistance[2].

Biochem/physiol Actions

Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16 S r-RNA. It inhibits translocation and elicits miscoding. Tobramycin binds to an RNA aptamer, which is structurally similar to the A site of 16S rRNA[2].

Tobramycin sulfate is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.

Packaging

100MG,500MG

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.

Disclaimer

Hygroscopic

Bezpečnostní informace

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H312 + H332,H360
• pcodes: P202 - P261 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Repr. 1B
• Skladovací třída: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges