SRP0324
MECP2 human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Synonyma:
MRX16, PPMX, RTS, methyl CpG binding protein 2 (Rett syndrome)
Přihlásit pro zobrazení organizačních a smluvních cen.
Vybrat velikost
Změnit zobrazení
| Vám/Skladová položka | Dostupnost | Cena |
|---|---|---|
50 μg | Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti. | 17 100,00 Kč |
O této položce
NACRES:
NA.32
UNSPSC Code:
12352202
17 100,00 Kč
Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.
Technický servis
Potřebujete pomoc? Náš tým zkušených odborníků je vám k dispozici.
Dovolte nám, abychom vám pomohlibiological source
human
recombinant
expressed in E. coli
assay
≥70% (SDS-PAGE)
form
aqueous solution
mol wt
36 kDa
packaging
pkg of 50 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... MECP2(4204)
General description
Human recombinant Methyl CpG binding Protein 2 (Rett syndrome) (MECP2), (GenBank Accession No. NM_004992), amino acids 78-162 with N-terminal GST-tag, MW= 36 kDa, expressed in an E. coli expression system.
Methyl-CpG binding protein 2 (MECP2) is encoded by the gene mapped to human chromosome Xq28.[1] Higher molecular weight form of hMeCP2 is expressed in frontal cortex nuclear and synaptic fractions, and in lymphoid cells. Fibroblast and lymphoblastoid strains of female patients with Rett syndrome and MeCP2 transfected cells also show expression of high molecular weight form of MeCP2.2The encoded chromosomal protein is characterized with the 80 amino acid-containing methyl-CpG binding domain, involved in chromosomal localization of the protein.
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Biochem/physiol Actions
Methyl-CpG binding protein 2 (MECP2) plays a vital role in regulation of a wide range of genes in the hypothalamus, and aids in both activation and repression of transcription.[2] Mutation of the gene leads to a severe neurodevelopmental disorder associated with hypotonia, spasticity, severe learning disability, delayed psychomotor development, and recurrent pulmonary infections in males.[1] Impairment in the expression of MeCP2 protein results in various neurological disorders such as Rett syndrome and Autism.
1 of 1
Tato položka | |||
|---|---|---|---|
| recombinant expressed in E. coli | recombinant - | recombinant - | recombinant expressed in baculovirus infected Sf9 cells |
| assay ≥70% (SDS-PAGE) | assay - | assay - | assay ≥48% (SDS-PAGE) |
| biological source human | biological source mouse | biological source mouse | biological source human |
| form aqueous solution | form buffered aqueous solution | form buffered aqueous solution | form aqueous solution |
| mol wt 36 kDa | mol wt - | mol wt antigen ~35.9 kDa | mol wt 53.6 kDa |
| packaging pkg of 50 μg | packaging - | packaging - | packaging pkg of 50 μg |
Skladovací třída
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Vyberte jednu z posledních verzí:
Již tento produkt vlastníte?
Dokumenty související s produkty, které jste v minulosti zakoupili, byly za účelem usnadnění shromážděny ve vaší Knihovně dokumentů.