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SML1666

4-Hydroxytamoxifen

Name: 4-Hydroxytamoxifen
Brand: SIGMA
Price: 7090 CZK

≥98% (HPLC), solution, Estrogen receptor antagonist

Synonyma:

4-OHT, cis/trans-4-Hydroxytamoxifen

Přihlásit pro zobrazení organizačních a smluvních cen.

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Velikost balení	Skladová položka	Dostupnost	Cena
1 mL		Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.	7 090,00 Kč

O této položce

Empirický vzorec (Hillův zápis):

C₂₆H₂₉NO₂

Číslo CAS:

68392-35-8

Molekulová hmotnost:

387.51

UNSPSC Code:

12352200

NACRES:

NA.77

Form:

solution

7 090,00 Kč

Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.

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Vlastnosti

Název produktu

4-Hydroxytamoxifen Ready Made Solution, 5 mg/mL in ethanol: isopropanol (95:5)

biological source

synthetic

Quality Segment

200

form

solution

concentration

5 mg/mL in ethanol: isopropanol (95:5)

shipped in

dry ice

storage temp.

−20°C

SMILES string

N(CCOc1ccc(cc1)\C(=C(\CC)/c3ccccc3)\c2ccc(cc2)O)(C)C

InChI

1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-

InChI key

TXUZVZSFRXZGTL-QPLCGJKRSA-N

Popis

Biochem/physiol Actions

4-Hydroxytamoxifen is an active metabolite of Tamoxifen.

4-Hydroxytamoxifen is an active metabolite of Tamoxifen. 4-Hydroxytamoxifen is formed by cytochrome P450 2D6 in human liver and is a potent and selective estrogen receptor antagonist. 4-Hydroxytamoxifen has been used to stimulate LC3 lipidation and to form autophagic vesicles in a superoxide-dependent manner. Tamoxifen and 4-Hydroxytamoxifen markedly induce cytochrome P450 3A4 (a major drug-metabolizing enzyme) in primary cultures of human hepatocytes. 4-Hydroxytamoxifen undergoes a cis-trans (E-Z) isomerization, a process that occurs in all common laboratory solvents.

Trans isoform of 4-hydroxytamoxifen possesses antiestrogenic activity, while the cis 4-hydroxytamoxifen serves as a key agonist for estrogen receptor. 4-Hydroxytamoxifen promotes apoptosis via activation of p38 pathway in breast cancer cell cultures.

Preparation Note

4-Hydroxytamoxifen is provided in a 13 mM solution. The recommended working concentration is 10-100 μM. Therefore, 4-Hydroxytamoxifen Ready Made Solution should be diluted 1:130 - 1:1,300 in cell culture media.

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

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Tato položka	H6278	H7904	SML2368
Sigma-Aldrich SML1666 4-Hydroxytamoxifen Ready Made Solution	Sigma-Aldrich H6278 4-Hydroxytamoxifen	Sigma-Aldrich H7904 (Z)-4-Hydroxytamoxifen	Sigma-Aldrich SML2368 (Z)-Endoxifen
form solution	form powder	form powder	form powder
Quality Level 200	Quality Level 300	Quality Level 300	Quality Level -
storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
shipped in dry ice	shipped in -	shipped in -	shipped in -
concentration 5 mg/mL in ethanol: isopropanol (95:5)	concentration -	concentration -	concentration -
biological source synthetic	biological source -	biological source -	biological source -