P6254

Prednisone

≥98% (HPLC), powder, anti-inflammatory activity

• Synonyma: 1,4-Pregnadiene-17α,21-diol-3,11,20-trione, 1-Cortisone, 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione, Dehydrocortisone
• Empirický vzorec (Hillův zápis): C₂₁H₂₆O₅
• Číslo CAS: 53-03-2
• Molekulová hmotnost: 358.43
• NACRES: NA.77
• PubChem Substance ID: 24898748
• UNSPSC Code: 12352200
• EC Number: 200-160-3
• MDL number: MFCD00003608
• Beilstein/REAXYS Number: 2065301
• Assay: ≥98%
• Form: powder

Vlastnosti

• Název produktu: Prednisone, ≥98%
• biological source: synthetic
• Quality Segment: 200
• sterility: non-sterile
• assay: ≥98%
• form: powder
• mp: 236-238 °C (lit.)
• solubility: chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to light yellow
• application(s): hematology
• shipped in: ambient
• storage temp.: room temp
• SMILES string: O=C1C=C[C@@]2(C)C(CC[C@]([C@@](CC[C@@]3(C(CO)=O)O)([H])[C@]3(C)C4)([H])[C@]2([H])C4=O)=C1
• InChI: 1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
• InChI key: XOFYZVNMUHMLCC-ZPOLXVRWSA-N
• Gene Information: human ... NR3C1(2908)

Popis

Application

Prednisone has been used in dimethyl sulfoxide stock suspension to inject into experimental mice and to analyze the effects of glucocorticoid steroid. It has also been used as a test drug, formulated with peanut butter to study the effects of daily administration of MIDD0301, by animal weight, organ weight and haematological analysis.

Biochem/physiol Actions

Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activity. It is useful in treating many disease states and has a half-life of 3.4 to 3.8 hours in plasma. Prednisone is metabolized to prednisolone, which is physiologically active.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Bezpečnostní informace

• pictograms: GHS08
• signalword: Warning
• hcodes: H373
• pcodes: P260 - P314 - P501
• Hazard Classifications: STOT RE 2
• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges