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Merck

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I5521

Monoclonal Anti-Interferon-γ antibody produced in mouse

clone 25718, purified immunoglobulin, lyophilized powder

Synonyma:

Anti-IFN-γ

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Velikost baleníSkladová položkaDostupnostCena
0.5 mg
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25 100,00 Kč

O této položce

UNSPSC Code:
51111800
NACRES:
NA.41
MDL number:
Conjugate:
unconjugated
Clone:
25718, monoclonal
Application:
ICC, Neutral
Citations:
5

25 100,00 Kč


Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.
K vašemu cílovému použití je dostupná rekombinantní protilátka bez obsahu konzervačních látek. Vyzkoušejte ZRB1620

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biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

25718, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

immunocytochemistry: 8-25 μg/mL using immersion fixed human peripheral blood mononuclear cells stimulated with PMA and ionomycin, neutralization: suitable

impurities

endotoxin, tested

isotype

IgG2a

UniProt accession no.

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IFNG(3458)

Immunogen

recombinant human interferon-γ, expressed and purified from Escherichia coli.

Biochem/physiol Actions

Interferons (IFNs) are cytokines that are secreted in response to viral or bacterial infections and tumorigenesis. IFN-γ binds to specific receptor complex consisting of IFNγR1 and IFNγR2. There are many pathways that are mediated by IFN-γ binding such as JAK/STAT1, AP-1, NF-κB, STAT3 and STAT5. IFN-γ is pleotropic and performs various functions related to immune response, inflammation, differentiation and activation of T cells, cell cycle and apoptosis.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose.

Preparation Note

Purified using protein A affinity chromatography.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Tato položka
I6784I5152SAB4700877
biological source

mouse

biological source

mouse

biological source

goat

biological source

mouse

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human, nonhuman primates

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

clone

25718, monoclonal

clone

5334, monoclonal

clone

polyclonal

clone

4S.B3, monoclonal

Gene Information

human ... IFNG(3458)

Gene Information

human ... IL2(3558)

Gene Information

human ... IFNGR1(3459)

Gene Information

human ... IFNG(3458)

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated


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Skladovací třída

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Osvědčení o analýze (COA)

Lot/Batch Number

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Sambit K Nanda et al.
Journal of virology, 80(15), 7555-7568 (2006-07-15)
Rinderpest virus (RPV) is a paramyxovirus closely related to the human pathogen Measles virus. It causes severe disease in cattle, buffalo, and some wild animals; although it can infect humans, it does not cause disease. Here, we demonstrate that RPV
Leonidas C Platanias
Nature reviews. Immunology, 5(5), 375-386 (2005-05-03)
Interferons are cytokines that have antiviral, antiproliferative and immunomodulatory effects. Because of these important properties, in the past two decades, major research efforts have been undertaken to understand the signalling mechanisms through which these cytokines induce their effects. Since the
Kate Schroder et al.
Journal of leukocyte biology, 75(2), 163-189 (2003-10-04)
Interferon-gamma (IFN-gamma) coordinates a diverse array of cellular programs through transcriptional regulation of immunologically relevant genes. This article reviews the current understanding of IFN-gamma ligand, receptor, signal transduction, and cellular effects with a focus on macrophage responses and to a



Globální číslo obchodní položky

Skladová položkaGTIN
I5521-.5MG04061832714585

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