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E1024

Sigma-Aldrich

Estradiol

meets USP testing specifications

Synonyma:

β-Estradiol, 1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
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About This Item

Empirický vzorec (Hillův zápis):
C18H24O2
Číslo CAS:
50-28-2
Molekulová hmotnost:
272.38
Beilstein/REAXYS Number:
1914275
EC Number:
200-023-8
MDL number:
MFCD00003693
UNSPSC Code:
12352104
PubChem Substance ID:
24894380
NACRES:
NA.21

agency

USP/NF
meets USP testing specifications

form

powder

mp

176-180 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C

InChI

1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

InChI key

VOXZDWNPVJITMN-ZBRFXRBCSA-N

Gene Information

human ... ESR1(2099) , ESR2(2100) , ESRRB(2103) , GPER(2852) , SERPINA6(866)
mouse ... Esr1(13982) , Esr2(13983) , Esrra(26379)
rat ... Afp(24177) , Ar(24208) , Esr1(24890) , Esr2(25149) , Shbg(24775)

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Související kategorie

Biochem/physiol Actions

The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

pictograms

Health hazardEnvironment
GHS08,GHS09

signalword

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

Osvědčení o analýze (COA)

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α-Estradiol powder, ≥98% (TLC)

Sigma-Aldrich

E8750

α-Estradiol

17β-Estradiol solution 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

E-060

17β-Estradiol solution

Progesterone meets USP testing specifications

Sigma-Aldrich

P3972

Progesterone

Estrone ≥99%

Sigma-Aldrich

E9750

Estrone

Estriol ≥97%

Sigma-Aldrich

E1253

Estriol

Progesterone ≥99%

Sigma-Aldrich

P0130

Progesterone

β-Estradiol 17-acetate ≥99%

Sigma-Aldrich

E7879

β-Estradiol 17-acetate

17β-Estradiol-2,3,4-13C3 solution ampule of 1 mL, Cerilliant®

Supelco

E-073

17β-Estradiol-2,3,4-13C3 solution

Martial Pré et al.
Plant physiology, 147(3), 1347-1357 (2008-05-10)
Plant defense against pathogens depends on the action of several endogenously produced hormones, including jasmonic acid (JA) and ethylene. In certain defense responses, JA and ethylene signaling pathways synergize to activate a specific set of defense genes. Here, we describe
Fiona C Baker et al.
Psychoneuroendocrinology, 60, 96-104 (2015-07-05)
The menopausal transition is marked by increased prevalence in disturbed sleep and insomnia, present in 40-60% of women, but evidence for a physiological basis for their sleep complaints is lacking. We aimed to quantify sleep disturbance and the underlying contribution
Agnete Overgaard et al.
Endocrinology, 155(10), 3945-3955 (2014-07-23)
Kisspeptin, neurokinin B (NKB) and dynorphin A are coexpressed in a population of neurons in the arcuate nucleus (ARC), termed KNDy neurons, which were recently recognized as important elements for the generation of GnRH pulses. However, the topographic distribution of
Hirotaka Ishii et al.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 13(4), 323-334 (2007-07-24)
It is believed that sex hormones are synthesized in the gonads and reach the brain via the blood circulation. In contrast with this view, the authors have demonstrated that sex hormones are also synthesized locally in the hippocampus and that
Yasushi Totoki et al.
Nature genetics, 46(12), 1267-1273 (2014-11-05)
Diverse epidemiological factors are associated with hepatocellular carcinoma (HCC) prevalence in different populations. However, the global landscape of the genetic changes in HCC genomes underpinning different epidemiological and ancestral backgrounds still remains uncharted. Here a collection of data from 503
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