D3900

Desipramine hydrochloride

≥98% (TLC), powder, imipramine metabolite

• Empirický vzorec (Hillův zápis): C₁₈H₂₂N₂ · HCl
• Číslo CAS: 58-28-6
• Molekulová hmotnost: 302.84
• NACRES: NA.77
• PubChem Substance ID: 24278094
• UNSPSC Code: 12352116
• EC Number: 200-373-1
• MDL number: MFCD00058108
• Assay: ≥98% (TLC)
• Form: powder

Vlastnosti

• Název produktu: Desipramine hydrochloride, ≥98% (TLC), powder
• Quality Segment: 100
• assay: ≥98% (TLC)
• form: powder
• color: white to off-white
• solubility: H₂O: 50 mg/mL
• originator: Sanofi Aventis
• storage temp.: 2-8°C
• SMILES string: Cl[H].CNCCCN1c2ccccc2CCc3ccccc13
• InChI: 1S/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H
• InChI key: XAEWZDYWZHIUCT-UHFFFAOYSA-N
• Gene Information: human ... SLC6A2(6530)

Popis

General description

Desipramine, a metabolite of imipramine and iofepramine is an active tricyclic antidepressant.

Application

Desipramine hydrochloride has been used:

• to prevent norepinephrine neuron degeneration and to maximize uptake into DA neurons
• to protect unselective damage to the noradrenergic system[1]
• as a norepinephrine re-uptake inhibitor to treat rats for lesioning

Biochem/physiol Actions

Desipramine is used to treat depression. It is also used to manage enuresis in children. Desipramine helps to eliminate the pain triggered by diabetic neuropathy.

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (K_i = 4 nM) than the serotonin transporter (K_i = 61 nM).

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Disclaimer

Hygroscopic

Bezpečnostní informace

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H315,H317,H319,H334,H335
• pcodes: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• target_organs: Respiratory system
• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves