C6305

Clozapine

≥98% (TLC), powder, D₄-dopamine receptor antagonist

• Synonyma: 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine
• Empirický vzorec (Hillův zápis): C₁₈H₁₉ClN₄
• Číslo CAS: 5786-21-0
• Molekulová hmotnost: 326.82
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277892
• NACRES: NA.77
• MDL number: MFCD00153785
• Form: powder

Vlastnosti

• Název produktu: Clozapine,
• form: powder
• Quality Segment: 300
• solubility: ethanol: 1 mg/mL, 0.1 M HCl: 30 mg/mL, DMSO: 4.8 mg/mL
• originator: Novartis
• SMILES string: CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24
• InChI: 1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
• InChI key: QZUDBNBUXVUHMW-UHFFFAOYSA-N
• Gene Information: human ... ADRA1A(148), ADRA2A(150), ADRA2C(152), CHRM1(1128), DRD2(1813), DRD3(1814), DRD4(1815), HRH1(3269), HRH4(59340), HTR2A(3356), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR6(3362), HTR7(3363), KCNH1(3756), KCNH2(3757), UGT1A4(54657) ; rat ... Adra1a(29412), Adra2a(25083), Adrb1(24925), Chrm1(25229), Drd1a(24316), Drd2(24318), Drd3(29238), Drd4(25432), Hrh1(24448), Htr1a(24473), Htr1b(25075), Htr2a(29595), Htr2b(29581), Htr2c(25187), Htr3a(79246), Htr7(65032), Slc6a4(25553)

Popis

Biochem/physiol Actions

Atypical antipsychotic compound. Selective antagonist for D₄-dopamine receptor. Antagonist at 5-HT_2A, 5-HT_2C, 5-HT₃, 5-HT₆, and 5-HT₇ serotonin receptors.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Bezpečnostní informace

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Skladovací třída: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable