C3742
Chk2 Inhibitor II hydrate
≥98% (HPLC)
Synonyma:
2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide hydrate
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| Velikost balení | Skladová položka | Dostupnost | Cena |
|---|---|---|---|
| 5 mg | Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti. | 5 490,00 Kč 4 666,50 Kč |
O této položce
Empirický vzorec (Hillův zápis):
C20H14ClN3O2 · xH2O
Číslo CAS:
Molekulová hmotnost:
363.80 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
4 666,50 Kč
Ceníková cena5 490,00 KčUložit 15 %Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.
Technický servis
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Dovolte nám, abychom vám pomohliQuality Level
assay
≥98% (HPLC)
form
solid
color
off-white to tan
solubility
DMSO: ≥2 mg/mL (warmed)
originator
Johnson & Johnson
storage temp.
2-8°C
SMILES string
O=C(C1=CC=C2C(N=C(C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3)N2)=C1)N
InChI
1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
InChI key
UXGJAOIJSROTTN-UHFFFAOYSA-N
Gene Information
human ... CHEK2(11200)
Biochem/physiol Actions
Chk2 Inhibitor II is a checkpoint kinase 2 inhibitor, which controls the p53 response to DNA breaks induced by radiation, leading to apoptosis. Protection of T-cells from apoptosis implies use as an adjuvant for radiation therapy in cancer.
Chk2 Inhibitor II is a checkpoint kinase 2 inhibitor, which controls the p53 response to DNA breaks induced by radiation, leading to apoptosis. Protection of T-cells from apoptosis implies use as an adjuvant for radiation therapy in cancer. IC50 = 15 nM; Ki = 37 nM. Chk2 Inhibitor II shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC50 = 12 μM and 17 μM, respectively). Chk2 Inhibitor II weakly inhibits a panel of 31 other kinases (<25% inhibition at a concentration of 10 μM and prevents apoptosis of human CD4+ and CD8+ T-cells subjected to ionizing radiation (EC50 = 3 μM and 7.6 μM, respectively).
Features and Benefits
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Tato položka | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay >98% (HPLC) |
| form solid | form solid | form solid | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: ≥2 mg/mL (warmed) | solubility DMSO: ≥12 mg/mL | solubility DMSO: 5 mg/mL | solubility DMSO: 10 mg/mL, clear |
| originator Johnson & Johnson | originator GlaxoSmithKline | originator - | originator GlaxoSmithKline |
Skladovací třída
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Globální číslo obchodní položky
| Skladová položka | GTIN |
|---|---|
| C3742-25MG | 04061832445267 |
| C3742-5MG | 04061832445274 |