B9938
Calycosin
≥98% (HPLC)
Synonyma:
3′,7-Dihydroxy-4′-methoxy-isoflavone, 3′-Hydroxyformononetin, Cyclosin
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| Velikost balení | Skladová položka | Dostupnost | Cena |
|---|---|---|---|
| 10 mg | Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti. | 9 230,00 Kč |
O této položce
Empirický vzorec (Hillův zápis):
C16H12O5
Číslo CAS:
Molekulová hmotnost:
284.26
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
9 230,00 Kč
Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.
Technický servis
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assay
≥98% (HPLC)
form
powder
color
white to light yellow
solubility
methanol: 1 mg/mL, clear, colorless
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
SMILES string
O=C1C(C(C=C2)=CC(O)=C2OC)=COC3=CC(O)=CC=C13
InChI
1S/C16H12O5/c1-20-14-5-2-9(6-13(14)19)15-8-12(18)11-4-3-10(17)7-16(11)21-15/h2-8,17,19H,1H3
InChI key
QAGGICSUEVNSGH-UHFFFAOYSA-N
General description
Application
Calycosin has been used:
- to study its effect on the repression of glioblastomas by having an inhibitory effect on the expression of tyrosine-protein kinase Met (c-Met)[1]
- to analyze its effect on the growth of nasopharyngeal carcinoma cells by modulating the long non-coding RNA, Ewing sarcoma-associated transcript 1(EWSAT1)[2]
- to evaluate its effect on the left ventricular ejection fraction in rat model with myocardial ischemia[3]
Biochem/physiol Actions
Calycosin exhibits various therapeutic properties such as anti-inflammatory, antioxidant, antiviral, and neuroprotective effects.[1][4] It is shown to exercise its anticarcinogenic effects against the cluster of breast cancer, osteosarcoma, hepatocellular carcinoma, and colorectal cancer.[2] It is also being promoted as a probable treatment for myocardial infarction due to its ability to hasten the process of angiogenesis and increase the expression of vascular endothelial growth factor (VEGF).[3][5] It has been found to show hyperpermeability induced by the conditions of low osmolarity.[4] Finally, calycosin is being suggested to be used as a prodrug for the treatment of hypoxia-related vascular diseases.[6]
Isoflavone and phytoestrogen isolated froma traditional Chinese medicinal herb. Calycosin induces angiogenesis in HUVEC and promotes proliferation of estrogen-receptor positive cells in vivo and in vitro. Also functions as a vasorelaxant on rat thoracic aorta.
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Tato položka | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥95.0% (HPLC) | assay ≥98% (HPLC) | assay - |
| form powder | form solid | form powder | form - |
| Quality Level 100 | Quality Level - | Quality Level 200 | Quality Level - |
| application(s) metabolomics | application(s) - | application(s) metabolomics | application(s) pharmaceutical (small molecule) |
| storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility methanol: 1 mg/mL, clear, colorless | solubility - | solubility - | solubility - |
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signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
Skladovací třída
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dokumenty související s produkty, které jste v minulosti zakoupili, byly za účelem usnadnění shromážděny ve vaší Knihovně dokumentů.
Guang Hu et al.
Xenobiotica; the fate of foreign compounds in biological systems, 42(3), 294-303 (2011-10-04)
Although zebrafish has become a popular animal model for drug discovery and screening, drug metabolism in zebrafish remains largely unknown. In this study, we probed the metabolic capability of zebrafish larvae with calycosin, one of the major isoflavone constituents of
Dongqing Zhang et al.
Oxidative medicine and cellular longevity, 2012, 209843-209843 (2012-08-01)
Flavonoids are found in most parts of plants and have been shown to have multiple biological activities such as anticancer, anti-inflammation, antibacteria, antivirus, and immune-stimulation. Existing data showed that the total flavonoids of Astragalus (TFA) can provide biological system with
Dongli Zhang et al.
Archives of biochemistry and biophysics, 691, 108478-108478 (2020-07-28)
Calycosin, a functional phytoestrogen isoflavone isolated from Radix astragali, has been shown to possess multiple pharmacological properties including anti-cancer activity. However, up to now, the anti-cancer effect and the related mechanism of calycosin on cervical cancer (CC) cells have not
Globální číslo obchodní položky
| Skladová položka | GTIN |
|---|---|
| B9938-10MG | 04061833047019 |