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A4377

S-(5′-Adenosyl)-L-methionine iodide

≥80% (spectrophotometric assay), suitable for cell culture

Synonyma:

AdoMet, SAM

Přihlásit pro zobrazení organizačních a smluvních cen.

Vybrat velikost

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Velikost baleníSkladová položkaDostupnostCena
5 mg
Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.
2 140,00 Kč
25 mg
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6 280,00 Kč
100 mg
Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.
18 700,00 Kč

O této položce

Empirický vzorec (Hillův zápis):
C15H23IN6O5S
Číslo CAS:
3493-13-8
Molekulová hmotnost:
526.35
NACRES:
NA.26
PubChem Substance ID:
24890852
UNSPSC Code:
12352209
EC Number:
222-486-5
MDL number:
MFCD00043192
Beilstein/REAXYS Number:
4120787

2 140,00 Kč

Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.
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Název produktu

S-(5′-Adenosyl)-L-methionine iodide, ≥80% (HPLC), ≥80% (spectrophotometric assay)

Quality Level

200

assay

≥80% (HPLC), ≥80% (spectrophotometric assay)

form

powder

technique(s)

cell culture | mammalian: suitable

color

white to off-white

solubility

H2O: 100 mg/mL

shipped in

dry ice

storage temp.

−20°C

SMILES string

[I-].C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23

InChI

1S/C15H22N6O5S.HI/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);1H/t7-,8+,10+,11+,14+,27?;/m0./s1

InChI key

XQMWYLXPEGFCFT-XKGORWRGSA-N

Application

S-(5′-Adenosyl)-L-methionine (SAM, AdoMet) is used as a primary methyl donor molecule in mammalian cell culture and the first step metabolite in methionine biosynthesis.

Biochem/physiol Actions

Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.

Analysis Note

Purity based on UV and HPLC.

Disclaimer

This material is very unstable at room temperature.

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Tato položka
A2408A7007E2153
S-(5′-Adenosyl)-L-methionine iodide ≥80% (HPLC), ≥80% (spectrophotometric assay)

Sigma-Aldrich

A4377

S-(5′-Adenosyl)-L-methionine iodide

S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt ≥80% (HPLC), ≥80% (spectrophotometric assay)

Sigma-Aldrich

A2408

S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt

S-(5′-Adenosyl)-L-methionine chloride dihydrochloride ≥75%

Sigma-Aldrich

A7007

S-(5′-Adenosyl)-L-methionine chloride dihydrochloride

E-Cadherin/Fc Chimera from mouse >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Sigma-Aldrich

E2153

E-Cadherin/Fc Chimera from mouse

form

powder

form

powder

form

powder

form

lyophilized powder

assay

≥80% (HPLC), ≥80% (spectrophotometric assay)

assay

≥80% (HPLC), ≥80% (spectrophotometric assay)

assay

≥75%

assay

>90% (SDS-PAGE)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

300

Quality Level

300

Quality Level

100

color

white to off-white

color

white to off-white

color

white to off-white

color

-

solubility

H2O: 100 mg/mL

solubility

H2O: 100 mg/mL

solubility

H2O: 100 mg/mL

solubility

-

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

Skladovací třída

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type N95 (US)

Vyberte jednu z posledních verzí:

Osvědčení o analýze (COA)

Lot/Batch Number
0000488961
0000488962
0000488963
0000488961
0000488963

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Potřebujete-li konkrétní verzi, můžete vyhledat daný certifikát podle čísla dávky nebo čísla šarže.

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Navštívit knihovnu dokumentů

Jianyu Zhang et al.
Journal of the American Chemical Society, 133(43), 17134-17137 (2011-10-01)
Human catechol-O-methyltransferase (COMT) catalyzes a methyl transfer from S-adenosylmethionine (AdoMet) to dopamine. Site-specific mutants at three positions (Tyr68, Trp38, and Val108) have been characterized with regard to product distribution, catalytic efficiency, and secondary kinetic isotope effects. The series of mutations
Laura Gomez-Santos et al.
Methods in molecular biology (Clifton, N.J.), 826, 133-149 (2011-12-15)
S-Adenosylmethionine, abbreviated as SAM, SAMe or AdoMet, is the principal methyl group donor in the mammalian cell and the first step metabolite of the methionine cycle, being synthesized by MAT (methionine adenosyltransferase) from methionine and ATP. About 60 years after
Ernst G Malygin et al.
Critical reviews in biochemistry and molecular biology, 47(2), 97-193 (2012-01-21)
The sequence-specific transfer of methyl groups from donor S-adenosyl-L-methionine (AdoMet) to certain positions of DNA-adenine or -cytosine residues by DNA methyltransferases (MTases) is a major form of epigenetic modification. It is virtually ubiquitous, except for some notable exceptions. Site-specific methylation
Zobrazit všechny související dokumenty

Globální číslo obchodní položky

Skladová položkaGTIN
A4377-25MG04061833368817
A4377-100MG04061833368770
A4377-5MG04061833369142

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. We are looking for one carbon metabolites in our serum samples, SAM is one of them. In our lab, we have S-(5′-Adenosyl)-L-methionine iodide (A4377). Can this chemical be used as one of the standards for the derivatisation-based GC-MS analysis?

    1 answer

    1. This product is not a standard and has not been tested for suitability for GC derivatization. Unfortunately, there is no SAM standard available in the product catalog.

      Helpful?

  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

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