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M0605000

Metformin hydrochloride

Name: Metformin hydrochloride
Brand: SIAL
Price: 3390 CZK

European Pharmacopoeia (EP) Reference Standard

Synonyma:

1,1-Dimethylbiguanide hydrochloride, Metformin

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Velikost balení	Skladová položka	Dostupnost	Cena
50 mg		Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.	3 390,00 Kč

O této položce

Lineární vzorec:

NH₂C(=NH)NHC(=NH)N(CH₃)₂ · HCl

Číslo CAS:

1115-70-4

Molekulová hmotnost:

165.62

NACRES:

NA.24

PubChem Substance ID:

329817811

UNSPSC Code:

41116107

MDL number:

MFCD00012582

3 390,00 Kč

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Vlastnosti

grade

pharmaceutical primary standard

API family

metformin

manufacturer/tradename

EDQM

mp

223-226 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cl[H].CN(C)C(=N)NC(N)=N

InChI

1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H

InChI key

OETHQSJEHLVLGH-UHFFFAOYSA-N

Gene Information

—

Popis

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Metformin hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Porovnat podobné položky

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1 of 1

Tato položka	1396309	BP227	PHR1084
M0605000 Metformin hydrochloride	USP 1396309 Metformin hydrochloride	BP227 Metformin hydrochloride	Supelco PHR1084 Metformin hydrochloride
manufacturer/tradename EDQM	manufacturer/tradename USP	manufacturer/tradename BP	manufacturer/tradename -
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade certified reference material, pharmaceutical secondary standard
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical pharmaceutical small molecule	application(s) pharmaceutical (small molecule)
format neat	format neat	format neat	format neat
agency EP Reference standard	agency -	agency -	agency traceable to Ph. Eur. M0605000, traceable to USP 1396309
Gene Information	Gene Information	Gene Information	Gene Information

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pictograms

GHS07

signalword

Warning

hcodes

H302,H319

pcodes

P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Skladovací třída

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Osvědčení o analýze (COA)

Lot/Batch Number

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Metformin Mitigates DPP-4 Inhibitor-Induced Breast Cancer Metastasis via Suppression of mTOR Signaling.

Emi Kawakita et al.

Molecular cancer research : MCR, 19(1), 61-73 (2020-10-01)

The biological influence of antidiabetic drugs on cancer cells and diabetic cancer patients has not yet been completely elucidated. We reported that a dipeptidyl peptidase (DPP)-4 inhibitor accelerates mammary cancer metastasis by inducing epithelial-mesenchymal transition (EMT) through the CXCL12/CXCR4/mTOR axis.

The Causal Role of Mitochondrial Dynamics in Regulating Innate Immunity in Diabetes.

Yen-Hsiang Chang et al.

Frontiers in endocrinology, 11, 445-445 (2020-08-28)

Background: Plenty of evidence suggested that chronic low-grade inflammation triggered by innate immunity activation contributes to the pathogenesis of type 2 diabetes (T2D). Using the trans-mitochondrial cybrid cell model, we have demonstrated that mitochondria independently take part in the pathological

Rapid and sensitive liquid chromatography-tandem mass spectrometric method for the quantitation of metformin in human plasma.

Yingwu Wang et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 808(2), 215-219 (2004-07-21)

A rapid and sensitive liquid chromatography-tandem mass spectrometric (LC-MS-MS) method for the determination of metformin in human plasma using phenformin as internal standard has been developed and validated. Sample preparation of plasma involved acidification with acetic acid, deproteination with acetonitrile

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Globální číslo obchodní položky

Skladová položka	GTIN
M0605000	04061833993439

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