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MAB4162

Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17

Name: Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17
Brand: MM
Price: 17600 CZK
Availability: InStock

clone MM4.17, Chemicon^®, from mouse

Synonyma:

P-glycoprotein, CD243, p170, Pgp

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Velikost balení	Skladová položka	Dostupnost	Cena
100 μg		Očekávané datum odeslání21. května 2026odAreál Kühne+Nagel spol. s r.o.	17 600,00 Kč

O této položce

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Clone:

MM4.17, monoclonal

Species reactivity:

human

Application:

FACS, IHC

Citations:

17 600,00 Kč

Očekávané datum odeslání21. května 2026podrobné informace

K vašemu cílovému použití je dostupná rekombinantní protilátka bez obsahu konzervačních látek. Vyzkoušejte ZRB1521

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Technický servis

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Vlastnosti

biological source

mouse

Quality Level

300

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

MM4.17, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon^®

technique(s)

flow cytometry: suitable, immunohistochemistry: suitable

isotype

IgG2aκ

NCBI accession no.

NM_000927.3

UniProt accession no.

P08183

shipped in

wet ice

Popis

Application

Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17 is an antibody against MDR1 for use in FC, IH.

Flow Cytometry

Immunohistochemistry on formalin fixed paraffin embedded sections

Confocal and Electron Microscopy

ELISA

Optimal working dilutions must be determined by end user.

Biochem/physiol Actions

Recognizes a mapped epitope in the extracellular Pgp domain and detects low-level Pgp expression in living (intact) human MDR cells (Cianfriglia, 2002). The epitope has been mapped to the single amino acid level using different techniques (Cianfriglia, 1994 and Poloni, 1995).

Physical form

Format: Purified

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Tato položka	MAB4334Z	MAB4120	P7965
Sigma-Aldrich MAB4162 Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17	Sigma-Aldrich MAB4334Z Anti-MDR1 Antibody, clone UIC2, azide free	Sigma-Aldrich MAB4120 Anti-MDR1 Antibody, clone JSB-1	Sigma-Aldrich P7965 Monoclonal Anti-P-Glycoprotein (MDR) antibody produced in mouse
clone MM4.17, monoclonal	clone UIC2, monoclonal	clone JSB-1, monoclonal	clone F4, monoclonal
species reactivity human	species reactivity primate, human	species reactivity human, hamster	species reactivity hamster, human
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form culture supernatant	antibody form ascites fluid
biological source mouse	biological source mouse	biological source mouse	biological source mouse
UniProt accession no. P08183	UniProt accession no. P08183	UniProt accession no. P08183	UniProt accession no. P08183
technique(s) flow cytometry: suitable, immunohistochemistry: suitable	technique(s) flow cytometry: suitable, immunofluorescence: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable	technique(s) flow cytometry: suitable, immunocytochemistry: suitable, immunohistochemistry: suitable (paraffin), western blot: suitable	technique(s) immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500 using human kidney sections, immunohistochemistry (frozen sections): suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, radioimmunoassay: suitable using cell-surface RIA, western blot: suitable

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wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Skladovací třída

12 - Non Combustible Liquids

Osvědčení o analýze (COA)

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Související obsah

Anti-MDR1, extracellular human specific Pgp, clone MM4.17 - Data Sheet

MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN]

A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells.

Paola Turella et al.

The Journal of biological chemistry, 281(33), 23725-23732 (2006-06-14)

The new glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) is cytotoxic toward P-glycoprotein-overexpressing tumor cell lines, i.e. CEM-VBL10, CEM-VBL100, and U-2 OS/DX580. The mechanism of cell death triggered by NBDHEX has been deeply investigated in leukemia cell lines. Kinetic data indicate a

Melanoma chemotherapy leads to the selection of ABCB5-expressing cells.

Marine Chartrain et al.

PloS one, 7(5), e36762-e36762 (2012-06-08)

Metastatic melanoma is the most aggressive skin cancer. Recently, phenotypically distinct subpopulations of tumor cells were identified. Among them, ABCB5-expressing cells were proposed to display an enhanced tumorigenicity with stem cell-like properties. In addition, ABCB5(+) cells are thought to participate

Role of SLC6A6 in promoting the survival and multidrug resistance of colorectal cancer.

Masahiro Yasunaga et al.

Scientific reports, 4, 4852-4852 (2014-05-02)

The treatment of colorectal cancer (CRC) might be improved by the identification of a signalling pathway that could be targeted with novel therapeutics. The results of this study indicate that the taurine transporter SLC6A6 is highly expressed in CRC cells

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Globální číslo obchodní položky

Skladová položka	GTIN
MAB4162	04053252660290

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