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8.00907

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

for peptide synthesis

Synonyma:

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

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Velikost baleníSkladová položkaDostupnostCena
500 mg
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861,00 Kč
1 g
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1 120,00 Kč
5 g
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3 120,00 Kč
25 g
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5 950,00 Kč

O této položce

Empirický vzorec (Hillův zápis):
C8H17N3 · xHCl
Číslo CAS:
Molekulová hmotnost:
155.24 (free base basis)
UNSPSC Code:
12352107
EC Index Number:
247-361-2
NACRES:
NA.22
MDL number:

861,00 Kč


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Název produktu

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, for synthesis

Quality Level

form

solid

reaction suitability

reaction type: Coupling Reactions

mp

110-115 °C

application(s)

peptide synthesis

storage temp.

−20°C (−15°C to −25°C)

SMILES string

Cl.N(CCCN(CC)C#N)(C)C

InChI

1S/C8H17N3.ClH/c1-4-11(8-9)7-5-6-10(2)3;/h4-7H2,1-3H3;1H

InChI key

FDXPUDRRFDHONO-UHFFFAOYSA-N

General description

N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride, also known as EDAC HCl or WSC, is a water-soluble condensing reagent. EDAC HCl is generally used to couple carboxylic acids with amines to form amides. The by-product urea is water-soluble and can be removed from immiscible reaction milieux by extraction with water. It is principally utilized in solution-phase peptide synthesis and as a zero-length crosslinker for protein modification.

Application

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC hydrochloride) can be used as:
  • A water-soluble carbodiimide to facilitate peptide coupling reactions in alcohols.
  • A coupling agent along with HOBt to synthesize poly(glutamic acid) (PGA) polypeptides for the creation of non-fouling polypeptides that could be useful in a variety of biomedical applications.
  • A coupling reagent for the efficient synthesis of teriflunomide at the industrial scale.

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Tato položka
E775003449E1769
form

solid

form

powder

form

powder

form

powder

storage temp.

−20°C (−15°C to −25°C)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

mp

110-115 °C

mp

110-115 °C (lit.)

mp

110-115 °C (lit.), 112-116 °C

mp

110-115 °C (lit.)

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

application(s)

peptide synthesis

application(s)

-

application(s)

-

application(s)

-

reaction suitability

reaction type: Coupling Reactions

reaction suitability

-

reaction suitability

-

reaction suitability

-


signalword

Danger

flash_point_f

Not applicable

flash_point_c

Not applicable

target_organs

Stomach,large intestine,lymph node

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral

Skladovací třída

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects



Osvědčení o analýze (COA)

Vyhledejte osvědčení Osvědčení o analýze (COA) zadáním čísla šarže/dávky těchto produktů. Čísla šarže a dávky lze nalézt na štítku produktu za slovy „Lot“ nebo „Batch“.

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Dokumenty související s produkty, které jste v minulosti zakoupili, byly za účelem usnadnění shromážděny ve vaší Knihovně dokumentů.

Navštívit knihovnu dokumentů



Effects of amounts of additives on peptide coupling mediated by a water-soluble carbodiimide in alcohols
Nozaki S
The Journal of Peptide Research, 54, 162-167 (1999)
Investigation of nonfouling polypeptides of poly (glutamic acid) with lysine side chains synthesized by EDCHCl/HOBt chemistry
Yang Q, et al.
Journal of Biomaterials Science. Polymer Edition, 25, 1717-1729 (2014)
EDC-promoted one-step synthesis of teriflunomide at the industrial scale
Wang L, et al.
Reaction Chemistry & Engineering, 2493-2496 (2022)



Globální číslo obchodní položky

Skladová položkaGTIN
800907850004027269278267
800907000504022536364254
800907002504022536364261
800907000104022536364247

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. The packaging instructions recommend storing the item under an inert gas, but the safety data sheet does not specify this requirement. Would it suffice to store it in a refrigerator at -20°C instead?

    1 answer
    1. The recommended long term storage of this item is -15°C to -25°C. Clearing the headspace of the vial with argon before resealing is recommended. The stability of the product when stored otherwise cannot be guaranteed.

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