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341216

NSC668394

≥95% (HPLC), solid, Ezrin inhibitor, Calbiochem®

Synonyma:

Ezrin Inhibitor, NSC668394, 7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione

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Velikost baleníSkladová položkaDostupnostCena
10 mg
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3 980,00 Kč

O této položce

Empirický vzorec (Hillův zápis):
C17H12Br2N2O3
Číslo CAS:
382605-72-3
Molekulová hmotnost:
452.10
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD28160708
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

3 980,00 Kč

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Název produktu

Ezrin Inhibitor, NSC668394, The Ezrin Inhibitor, NSC668394 controls the biological activity of Ezrin.

Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

red-orange

solubility

DMSO: 50 mg/mL, clear, red-orange

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C1C=C(NCCC2=CC(Br)=C(O)C(Br)=C2)C(C3=C1C=CC=N3)=O

InChI key

OHPHDPYJEHZGDE-UHFFFAOYSA-N

General description

A cell-permeable, quinoline that binds directly to ezrin (Kd = 12.6 µM) in a reversible manner, and inhibits PKCι-mediated ezrin phosphorylation at Thr567 (IC50 = 8.1 µM) and ezrin-actin binding, in vitro. It also inhibits murine osteosarcoma K7M2 cell invasion in a monolayer of HUVEC cells, dose-dependently, from 1 to 10 µM. At 10 µM, it causes a unique developmental defect in zebrafish, characterized by reduced motility of eye progenitor cells. Furthermore, this small molecule prevents metastatic growth in an ex vivo mouse lung organ culture assay at 10 µM and attenuates ezrin-dependent OS metastatic growth in mouse lung model in vivo at 2.26 mg/kg/day.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Bulut, G., et al. 2011. Oncogene31, 269.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Tato položka
681674444966238811
Ezrin Inhibitor, NSC668394 The Ezrin Inhibitor, NSC668394 controls the biological activity of Ezrin.

Sigma-Aldrich

341216

Ezrin Inhibitor, NSC668394

Wnt Pathway Inhibitor XI, CCT036477 The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

681674

Wnt Pathway Inhibitor XI, CCT036477

MEK1/2 Inhibitor III The MEK1/2 Inhibitor III, also referenced under CAS 391210-10-9, controls the biological activity of MEK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

444966

MEK1/2 Inhibitor III

Cdk9 Inhibitor II The Cdk9 Inhibitor II, also referenced under CAS 140651-18-9, controls the biological activity of Cdk9. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

238811

Cdk9 Inhibitor II

form

solid

form

solid

form

solid

form

solid

assay

≥95% (HPLC)

assay

≥95% (1H-NMR)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 50 mg/mL, clear, red-orange

solubility

DMSO: 50 mg/mL

solubility

DMSO: 20 mg/mL

solubility

DMSO: 10 mg/mL, ethanol: 5 mg/mL

Skladovací třída

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Osvědčení o analýze (COA)

Vyhledejte osvědčení Osvědčení o analýze (COA) zadáním čísla šarže/dávky těchto produktů. Čísla šarže a dávky lze nalézt na štítku produktu za slovy „Lot“ nebo „Batch“.

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Globální číslo obchodní položky

Skladová položkaGTIN
341216-10MG04055977215489

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