219502

Cathepsin L Inhibitor, CAA0225

• Synonyma: Cathepsin L Inhibitor, CAA0225
• Empirický vzorec (Hillův zápis): C₂₈H₂₉N₃O₅
• Molekulová hmotnost: 487.55
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥95% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze

Vlastnosti

• assay: ≥95% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 100 mg/mL
• shipped in: wet ice
• storage temp.: −20°C

Popis

General description

An epoxysuccinyl peptide highly selective for rat liver cathepsin L (IC₅₀ = 1.9 nM), while exhibiting little to no effect on rat liver cathepsin B at concentrations higher than 1000-5000 nM, in vitro. During autophagy, it has been shown through immunoblotting that CAA0225 (10 µg/ml) effectively inhibits the degradation of LC3-II and GABARAP compared to control, in nutrient-deprived HeLa and Huh-7 cells.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Takahashi, K., et al. 2009. Biol. Pharm. Bull.32, 475.
Ueno, T., et al. 2009. Autophagy5, 878.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable