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S166

Saclofen

solid

Sinônimo(s):

β-(Aminomethyl)-4-chlorobenzeneethanesulfonic acid

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Tamanho da embalagemSKUDisponibilidadePreço
5 mg
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R$ 2.601,00

Sobre este item

Fórmula empírica (Notação de Hill):
C9H12ClNO3S
Número CAS:
125464-42-8
Peso molecular:
249.71
NACRES:
NA.32
PubChem Substance ID:
329824485
UNSPSC Code:
51111800
MDL number:
MFCD00216817
Form:
solid
Quality level:
200

R$ 2.601,00

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form

solid

Quality Level

200

color

white

solubility

0.1 M NaOH: 20 mg/mL

SMILES string

NCC(CS(O)(=O)=O)c1ccc(Cl)cc1

InChI

1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)

InChI key

JYLNVJYYQQXNEK-UHFFFAOYSA-N

Gene Information

human ... GABBR1(2550), GABBR2(9568)
mouse ... GABBR1(54393), GABBR2(242425)
rat ... GABBR1(81657), GABBR2(83633)

Application

Saclofen has been used to prevent the inhibitory action of oxytocin on capsaicin-induced glutamatergic spontaneous excitatory transmission in rat neurons.[1]
Saclofen has been used as a GABAB receptor antagonist to study the analgesic effect of repeated injections of oxycodone in rats.

Biochem/physiol Actions

Saclofen might possess sympathetic nervous system-dependent anti-inflammatory action.[2]
Saclofen is the sulphonic analog of baclofen and is a selective GABAB receptor antagonist.

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Este Item
A6566M196B5399
Saclofen solid

Sigma-Aldrich

S166

Saclofen

2-Hydroxysaclofen ≥98% (TLC), solid

Sigma-Aldrich

A6566

2-Hydroxysaclofen

(+)-α-Methyl-4-carboxyphenylglycine solid

Sigma-Aldrich

M196

(+)-α-Methyl-4-carboxyphenylglycine

(±)-Baclofen ≥98% (HPLC), solid

Sigma-Aldrich

B5399

(±)-Baclofen

form

solid

form

solid

form

solid

form

solid

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

solubility

0.1 M NaOH: 20 mg/mL

solubility

H2O: 1 mg/mL, 0.1 M HCl: 1.2 mg/mL, methanol: 1.4 mg/mL, DMSO: 28 mg/mL, 0.1 M NaOH: 9.5 mg/mL

solubility

0.1 M NaOH: 15 mg/mL

solubility

1 M HCl: 50 mg/mL

color

white

color

white

color

-

color

white to very faintly yellow

Gene Information

human ... GABBR1(2550), GABBR2(9568)
mouse ... GABBR1(54393), GABBR2(242425)
rat ... GABBR1(81657), GABBR2(83633)

Gene Information

human ... GABBR1(2550), GABBR2(9568)

Gene Information

rat ... Grm1(24414)

Gene Information

human ... GABBR1(2550), GABBR2(9568)
rat ... Gabbr1(81657), Gabra2(29706)

Classe de armazenamento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
0000544335
0000544335
0000510273
0000510273
0000500585

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Gabriel S Bassi et al.
Naunyn-Schmiedeberg's archives of pharmacology, 389(8), 851-861 (2016-04-24)
Recent studies have demonstrated that the central nervous system controls inflammatory responses by activating complex efferent neuroimmune pathways. The present study was designed to evaluate the role that central gamma-aminobutyric acid type B (GABA-B) receptor plays in neutrophil migration in
Mahinda Kommalage et al.
European journal of pharmacology, 525(1-3), 69-73 (2005-11-22)
It has been shown that analgesics such as morphine, lidocaine and clonidine increase the release of spinal acetylcholine. Acetylcholine may therefore play an important role in the regulation of spinal pain threshold. Since behavioral as well as in vitro studies
Cord Blood-Derived Neurons Are Originated from CD133+/CD34 Stem/Progenitor Cells in a Cell-to-Cell Contact Dependent Manner
Vincent Z
Stem Cells and Development (2005)
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Número de item de comércio global

SKUGTIN
SAB5701894-100UL04065267678719
SAB5700317-100UL04065265172622
SAB5701958-100UL04065267679358
S166-5MG04061836912925

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