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Merck

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E2128

β-Estradiol 3-(β-D-glucuronide) 17-sulfate dipotassium salt

Sinônimo(s):

1,3,5(10)-Estratriene-3,17β-diol 3-glucuronide 17-sulfate, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-glucuronide 17-sulfate

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Sobre este item

Fórmula linear:
C24H30O11SK2
Número CAS:
Peso molecular:
604.75
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥98% (TLC)
Form:
powder
Quality level:


sterility

non-sterile

Quality Level

assay

≥98% (TLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless

shipped in

ambient

storage temp.

−20°C

SMILES string

[K].CC12CCC3C(CCc4cc(OC5OC(C(O)C(O)C5O)C(O)=O)ccc34)C1CCC2OS(O)(=O)=O

InChI

1S/C24H32O11S.K.H/c1-24-9-8-14-13-5-3-12(33-23-20(27)18(25)19(26)21(34-23)22(28)29)10-11(13)2-4-15(14)16(24)6-7-17(24)35-36(30,31)32;;/h3,5,10,14-21,23,25-27H,2,4,6-9H2,1H3,(H,28,29)(H,30,31,32);;

InChI key

HHYDRCVKADTNKW-UHFFFAOYSA-N

Biochem/physiol Actions

Estradiol is derived from estrogen and it exists as a conjugate as sulfate and glucuronides.[1] This conjugation enables in bringing down the estradiol hormonal activity and aids in eliminating them through excretion.[2]

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Este Item
E2127E1127E9505
assay

≥98% (TLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥93%

form

powder

form

powder

form

powder

form

powder

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

room temp

solubility

water: 50 mg/mL, clear, colorless

solubility

water: 10 mg/mL, clear to slightly hazy

solubility

0.1 M NaOH: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

methanol: 9.80-10.20 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient


pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

Classe de armazenamento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges



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B T Zhu et al.
Carcinogenesis, 19(1), 1-27 (1998-02-24)
Cytochrome P450 enzymes that metabolize estrogens are expressed in the mammary gland, uterus, brain and other target tissues for estrogen action, and this results in the formation of hydroxylated estrogens in these tissues. Estradiol metabolites formed in target tissues at
H Kuhl
Climacteric : the journal of the International Menopause Society, 8 Suppl 1, 3-63 (2005-08-23)
This review comprises the pharmacokinetics and pharmacodynamics of natural and synthetic estrogens and progestogens used in contraception and therapy, with special consideration of hormone replacement therapy. The paper describes the mechanisms of action, the relation between structure and hormonal activity



Número de item de comércio global

SKUGTIN
E2128-25MG04061832849836
E2128-5MG04061832849843

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