C239

CNQX disodium salt hydrate

≥98% (HPLC), solid, AMPA/kainate receptor antagonist.

• Sinônimo(s): 6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate
• Fórmula empírica (Notação de Hill): C₉H₂N₄Na₂O₄ · xH₂O
• Número CAS: 115066-14-3
• Peso molecular: 276.12 (anhydrous basis)
• Número MDL: MFCD09953908
• Código UNSPSC: 12352200
• ID de substância PubChem: 24277972
• NACRES: NA.77

Propriedades

• Nome do produto: CNQX disodium salt hydrate, ≥98% (HPLC), solid
• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: solid
• condição de armazenamento: protect from light
• cor: orange to red
• solubilidade: H₂O: >2 mg/mL (warmed)
• cadeia de caracteres SMILES: O.[Na+].[Na+].[O-]c1nc2cc(C#N)c(cc2nc1[O-])[N+]([O-])=O
• InChI: 1S/C9H4N4O4.2Na.H2O/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;;/h1-2H,(H,11,14)(H,12,15);;;1H2/q;2*+1;/p-2
• chave InChI: LCDWHGXMFAZHEO-UHFFFAOYSA-L
• Informações sobre genes: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) , GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893)

Descrição

Aplicação

CNQX disodium salt hydrate has been used as:

• as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)
• as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)
• as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)

Ações bioquímicas/fisiológicas

CNQX(6-cyano-7-nitroquinoxaline-2,3-dioneis) is a potent, competitive AMPA/kainate receptor antagonist.[1] It is a quinoxaline derivative and also an antagonist for non-N-methyl-d-aspartate (non-NMDA) glutamate receptor. CNQX mediates depolarization thalamic reticular nucleus via α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs).[2] It displays micromolar affinity towards AMPA/kainate receptor.[3]

Potent, competitive AMPA/kainate receptor antagonist.

Características e benefícios

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Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)