N183

NBQX disodium salt hydrate

≥98% (HPLC), lyophilized powder, neuroprotective AMPA/kainate glutamate receptor antagonist

• Sinônimo(s): 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide disodium salt hydrate, FG 9202 disodium salt hydrate
• Fórmula empírica (Notação de Hill): C₁₂H₆N₄Na₂O₆S · xH₂O
• Número CAS: 118876-58-7
• Peso molecular: 380.24 (anhydrous basis)
• Número MDL: MFCD12910445
• Código UNSPSC: 12352200
• ID de substância PubChem: 24277996
• NACRES: NA.77

Propriedades

• product name: NBQX disodium salt hydrate, ≥98% (HPLC)
• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: lyophilized powder
• condição de armazenamento: desiccated
• cor: , brown to dark red-brown
• solubilidade: H₂O: >10 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O.[Na+].[Na+].NS(=O)(=O)c1cccc2c1c(cc3nc([O-])c([O-])nc23)[N+]([O-])=O
• InChI: 1S/C12H8N4O6S.2Na.H2O/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6;;;/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22);;;1H2/q;2*+1;/p-2
• chave InChI: LQSCHRKYVVVUFA-UHFFFAOYSA-L
• Informações sobre genes: human ... GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893) , GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK4(2900) , GRIK5(2901)

Descrição

Aplicação

NBQX disodium salt hydrate has been used:

• in N-methyl-D-aspartate receptor (NMDAR) kinetic studies
• as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist for the electrophysiological studies cultured neurons
• in the extracellular solution for current/voltage (I/V) relationship and rectification index experiments in excitatory postsynaptic currents (EPSCs) mediated by NMDA receptors (EPSC_NMDAR)

Ações bioquímicas/fisiológicas

NBQX disodium salt hydrate is a neuroprotective AMPA/kainate glutamate receptor antagonist.

Características e benefícios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H315,H319,H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves