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C4142

Capreomycin sulfate from Streptomyces capreolus

Name: Capreomycin sulfate from <I>Streptomyces capreolus</I>
Brand: SIGMA

antibacterial peptide

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Sobre este item

Número CAS:

1405-37-4

NACRES:

NA.85

PubChem Substance ID:

24892668

UNSPSC Code:

51281628

EC Number:

215-776-8

MDL number:

MFCD00079032

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Propriedades

Quality Segment

200

form

powder

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria

mode of action

DNA synthesis | interferes

storage temp.

−20°C

SMILES string

OS(O)(=O)=O.NCCC[C@H](N)C(=O)NC[C@H]1NC(=O)[C@H](CO)NC(=O)[C@H](N)CNC(=O)[C@@H](NC(=O)\C(NC1=O)=C\NC(N)=O)[C@H]2CCNC(=N)N2

InChI

1S/C24H42N14O8.H2O4S/c25-4-1-2-10(26)17(40)32-7-13-19(42)34-14(8-33-24(29)46)20(43)38-16(12-3-5-30-23(28)37-12)22(45)31-6-11(27)18(41)36-15(9-39)21(44)35-13;1-5(2,3)4/h8,10-13,15-16,39H,1-7,9,25-27H2,(H,31,45)(H,32,40)(H,34,42)(H,35,44)(H,36,41)(H,38,43)(H3,28,30,37)(H3,29,33,46);(H2,1,2,3,4)/b14-8-;/t10-,11+,12?,13+,15-,16-;/m0./s1

InChI key

LFFNIXQXRKNZCE-UBBQZPMLSA-N

Descrição

Application

Capreomycin is used to study bacterial ribosomal subunit interactions and translocation processes during protein synthesis. It is a second line antibiotic and is used to study multidrug-resistant tuberculosis.[1][2]

Biochem/physiol Actions

Capreomycin is a cyclic peptide antibiotic that is often grouped with aminoglycosides. It binds across the ribosomal interface involving 23S rRNA helix 69 (H69) and 16S rRNA helix 44 (h44).[3]

Preparation Note

Sparingly soluble in water.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

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Este Item	K4013	K1637	G1424
Sigma-Aldrich C4142 Capreomycin sulfate from Streptomyces capreolus	Sigma-Aldrich K4013 Kasugamycin hydrochloride from Streptomyces kasugaensis	Sigma-Aldrich K1637 Canamicina	Sigma-Aldrich G1424 Globomycin from Streptomyces hagronensis
mode of action DNA synthesis \| interferes	mode of action protein synthesis \| interferes	mode of action protein synthesis \| interferes	mode of action enzyme \| inhibits
antibiotic activity spectrum Gram-negative bacteria, mycobacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma	antibiotic activity spectrum Gram-negative bacteria
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form powder	form powder	form powder	form powder
storage temp. −20°C	storage temp. 2-8°C	storage temp. -	storage temp. −20°C

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H302 + H312 + H332,H360

pcodes

P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 1B

Classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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