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C141

Sigma-Aldrich

CGS-21680 hydrochloride hydrate

solid

Sinônimo(s):

2-p-(2-Carboxyethyl)phenethylamino-5′-N-ethylcarboxamidoadenosine hydrochloride hydrate

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About This Item

Fórmula empírica (Notação de Hill):
C23H29N7O6 · HCl · xH2O
Número CAS:
124182-57-6
Peso molecular:
535.98 (anhydrous basis)
Número MDL:
MFCD11045878
Código UNSPSC:
12352200
ID de substância PubChem:
24277698
NACRES:
NA.77

Ensaio

≥98% (HPLC)

Nível de qualidade

100

forma

solid

condição de armazenamento

desiccated

cor

white

solubilidade

DMSO: >10 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 20 mg/mL

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

O.Cl.CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)nc(NCCc4ccc(CCC(O)=O)cc4)nc23

InChI

1S/C23H29N7O6.ClH.H2O/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32;;/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29);1H;1H2/t16-,17+,18-,22+;;/m0../s1

chave InChI

VIRPCGAECNOLOO-VBQNEDDFSA-N

Informações sobre genes

human ... ADORA2A(135) , ADORA2B(136)

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Ações bioquímicas/fisiológicas

Adenosine receptor agonist, which possesses selectivity for A2 verses A1 receptors.

Atenção

Hygroscopic

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sigma-Aldrich

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The accumulation of specific metabolic intermediates is known to promote cancer progression. We analyzed the role of 4-pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR), a nucleotide metabolite that accumulates in the blood of cancer patients, using the 4T1 murine in vivo breast cancer model, and
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Reducing neuroinflammatory damage is an effective strategy for treating white-matter damage (WMD) in premature infants. Caffeine can ameliorate hypoxia-ischemia-induced brain WMD; however, its neuroprotective effect and mechanism against hypoxic-ischemic WMD remain unclear. We used 3-day-old Sprague-Dawley rats to establish a
J W Phillis
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The A2 selective adenosine receptor agonist 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine (CGS 21680) depressed the spontaneous, acetylcholine- and glutamate-evoked firing of rat cerebral sensorimotor cortical neurons. Iontophoretically applied CGS 21680 was equipotent with adenosine as a depressant and its actions were antagonized by 8-p-sulphophenyltheophylline
N Levens et al.
The Journal of pharmacology and experimental therapeutics, 257(3), 1005-1012 (1991-06-01)
This study compares the renal actions of the A2 selective adenosine agonist, CGS 21680A, with the A1 selective adenosine agonist, N6-cyclopentyladenosine (CPA), and the nonselective agonist, 5'-N-ethylcarboxamide adenosine (NECA), in the anesthetized dog. Initial receptor binding studies in dog brain
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