344827
Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose
2F-Peracetyl-Fucose is a cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic.
Sinônimo(s):
Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose, (3S,4R,5R,6S)-3-fluoro-6-methyltetrahydro-2H-pyran-2,4,5-triyl triacetate
Faça login para ver os preços organizacionais e de contrato.
Selecione um tamanho
Alterar visualização
| Tamanho da embalagem | SKU | Disponibilidade | Preço |
|---|
Sobre este item
Fórmula empírica (Notação de Hill):
C12H17FO7
Peso molecular:
292.26
NACRES:
NA.77
UNSPSC Code:
12352111
Assay:
≥98% (NMR)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Preço e disponibilidade não estão disponíveis no momento.
Assistência Técnica
Precisa de ajuda? Nossa equipe de cientistas experientes está à sua disposição.
Estamos aqui para ajudarQuality Level
assay
≥98% (NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic. Treatment of HL-60 cells with this inhibitor shows complete abolition of Lewis-X and SLex within 3 days. Also abolishes P-selectin binding and exhibits faster rolling cells on E-selectin and P-selectin coated surfaces. Does not affect cell viability or their doubling time even at 200 µM levels.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Fucosyltransferase
Fucosyltransferase
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Rillahan, C., et al. 2012.. Nat. Chem. Bio.8, 661.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
1 of 1
Este Item | |||
|---|---|---|---|
| assay ≥98% (NMR) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (NMR) |
| form solid | form solid | form solid | form solid |
| Quality Level 300 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| storage temp. −20°C | storage temp. −70°C | storage temp. 2-8°C | storage temp. −20°C |
| storage condition OK to freeze, protect from light | storage condition OK to freeze, protect from light | storage condition OK to freeze, protect from light | storage condition OK to freeze |
Classe de armazenamento
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Martina Zimmermann et al.
Biotechnology and bioengineering, 118(5), 1818-1831 (2021-01-28)
The reduction of antibody core-fucosylation is known to enhance antibody-dependent cellular cytotoxicity (ADCC). In this study, 5-Thio-l-Fucose (ThioFuc) was investigated as a media and feed supplement for modulating the fucosylation profile of therapeutic proteins and, thereby, improving the resulting effector
Natalie K Thulin et al.
Cell reports, 31(6), 107642-107642 (2020-05-14)
Infant mortality from dengue disease is a devastating global health burden that could be minimized with the ability to identify susceptibility for severe disease prior to infection. Although most primary infant dengue infections are asymptomatic, maternally derived anti-dengue immunoglobulin G
Sotiria Pinioti et al.
Cancer immunology research, 11(12), 1611-1629 (2023-11-07)
Forkhead box P3 (Foxp3)-expressing regulatory T cells (Treg) are the guardians of controlled immune reactions and prevent the development of autoimmune diseases. However, in the tumor context, their increased number suppresses antitumor immune responses, indicating the importance of understanding the
Número de item de comércio global
| SKU | GTIN |
|---|---|
| 344827-10MG | 04055977214833 |