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Merck

T3452

Toloxatone

≥98% (HPLC), solid

Synonim(y):

5-(Hydroxymethyl)-3-(3-methylphenyl)-2-oxazolidinone, Humoryl

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10 MG

480,00 zł

50 MG

2070,00 zł

480,00 zł

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C11H13NO3
Numer CAS:
29218-27-7
Masa cząsteczkowa:
207.23
NACRES:
NA.77
PubChem Substance ID:
329826767
UNSPSC Code:
12161501
EC Number:
249-522-2
MDL number:
MFCD00865391
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
desiccated

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Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

Cc1cccc(c1)N2CC(CO)OC2=O

InChI

1S/C11H13NO3/c1-8-3-2-4-9(5-8)12-6-10(7-13)15-11(12)14/h2-5,10,13H,6-7H2,1H3

InChI key

MXUNKHLAEDCYJL-UHFFFAOYSA-N

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Ta pozycja
SML0248SML0103SML1058
Toloxatone ≥98% (HPLC), solid

Sigma-Aldrich

T3452

Toloxatone

Zolmitriptan ≥98% (HPLC)

Sigma-Aldrich

SML0248

Zolmitriptan

AMTB hydrate ≥98% (HPLC)

Sigma-Aldrich

SML0103

AMTB hydrate

PBIT ≥98% (HPLC)

Sigma-Aldrich

SML1058

PBIT

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: >10 mg/mL

solubility

DMSO: ≥5 mg/mL

solubility

DMSO: ≥10 mg/mL

solubility

DMSO: 10 mg/mL, clear (warmed)

storage condition

desiccated

storage condition

-

storage condition

desiccated

storage condition

-

Biochem/physiol Actions

Toloxatone is a reversible monoamine oxidase A inhibitor (MAOI) and antidepressant.
Toloxatone is a reversible monoamine oxidase A inhibitor (MAOI) and antidepressant. Toloxatone belongs to the aryloxazolidinones, a relatively new class of reversible monoamine oxidase A inhibitors (MAOI). Studies show that derivatives such as 3-aryloxazolidin-2-one (oxazolidinones), which are regularly used to treat gram positive infections, represent a new class of reversible as well as irreversible inhibitors for MAO-A and MAO-B enzymes that are able to inhibit protein synthesis and also used for neurodegenerative-type pathologies.

Preparation Note

Toloxatone is soluble in DMSO at a concentration that is greater than 10 mg/ml.
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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number
127K46092
127K46091
127K4609

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Robert Skibiński et al.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 26(4), 467-480 (2018-05-31)
Forced degradation of toloxatone in solutions under basic, acidic, neutral, photo UV-VIS, photo UVC and oxidative stress conditions was investigated and structural elucidation of its degradation products was performed with the use of UHPLC system coupled ESI-Q-TOF mass spectrometer. Eight
Jeong Hyun Heo et al.
Scientific reports, 10(1), 21695-21695 (2020-12-12)
Cholinesterase (ChE) and monoamine oxidase (MAO) inhibitors have been attracted as candidate treatments for Alzheimer's disease (AD). Fifteen khellactone-type coumarins from the roots of Peucedanum japonicum Thunberg were tested for acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and MAO inhibitory activities. Compound 3'-angeloyl-4'-(2-methylbutyryl)khellactone
Seung Cheol Baek et al.
Bioorganic chemistry, 83, 317-325 (2018-11-06)
Three flavanones and two flavones were isolated from the leaves of Prunus padus var. seoulensis by the activity-guided screening for new monoamine oxidase (MAO) inhibitors. Among the compounds isolated, rhamnocitrin (5) was found to potently and selectively inhibit human MAO-A
P Lemoine et al.
Psychopharmacology, 106 Suppl, S118-S119 (1992-01-01)
A double-blind comparison of moclobemide and toloxatone was performed in adult out-patients diagnosed as suffering from a major depressive disorder. Parallel groups of patients received moclobemide, 450 mg/day (n = 135) or toloxatone, 1000 mg/day (n = 133) for 28
Geum Seok Jeong et al.
Molecules (Basel, Switzerland), 25(17) (2020-08-30)
Eight compounds were isolated from the roots of Glycyrrhiza uralensis and tested for cholinesterase (ChE) and monoamine oxidase (MAO) inhibitory activities. The coumarin glycyrol (GC) effectively inhibited butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) with IC50 values of 7.22 and 14.77 µM
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Produkty

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

Numer pozycji handlu globalnego

SKUNUMER GTIN
T3452-50MG04061832931555
T3452-10MG04061832931548

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