SML0103

AMTB hydrate

Name: AMTB hydrate
Brand: SIGMA
Price: 574 PLN

≥98% (HPLC)

Synonim(y):

N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)-benzamide hydrochloride (1:1) hyclate

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5 MG

574,00 zł

25 MG

1572,50 zł

574,00 zł

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₂₃H₂₆N₂O₂S·HCl · xH₂O

Numer CAS:

926023-82-7

Masa cząsteczkowa:

430.99 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

329825160

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

O=C(C1=C(OCC2=C(C)C=CC=C2)C=CC=C1)N(CCCN)CC3=CC=CS3.Cl.O

InChI

1S/C23H26N2O2S.ClH.H2O/c1-18-8-2-3-9-19(18)17-27-22-12-5-4-11-21(22)23(26)25(14-7-13-24)16-20-10-6-15-28-20;;/h2-6,8-12,15H,7,13-14,16-17,24H2,1H3;1H;1H2

InChI key

RTYVTAQFASBIDN-UHFFFAOYSA-N

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Ta pozycja	SML0893	SML0608	G5793
Sigma-Aldrich SML0103 AMTB hydrate	Sigma-Aldrich SML0893 M8-B hydrochloride	Sigma-Aldrich SML0608 A-412997 dihydrochloride	Sigma-Aldrich G5793 GR 127935 hydrochloride hydrate
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay >98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. room temp	storage temp. 2-8°C
storage condition desiccated	storage condition desiccated	storage condition desiccated	storage condition desiccated
solubility DMSO: ≥10 mg/mL	solubility H₂O: 2 mg/mL, clear (warmed)	solubility H₂O: 20 mg/mL, clear	solubility DMSO: 10 mg/mL, clear

Application

AMTB hydrate has been used as an inhibitor of transient receptor potential cation channel, subfamily melastatin, member 8 (TRPM8) in breast cancer cells[1] and murine T cells.[2]

Biochem/physiol Actions

AMTB is a 2-benzyloxy-benzoic acid amide derivative,[1] which also inhibits voltage-gated sodium channels (Nav) and their isoforms.[1]

AMTB is a TRPM8 ion channel blocker

AMTB is a TRPM8-selective antagonist with no cross reactivity to TRPV1 or 4. The pIC50 of icilin activation of TRPM8 is 6.23 i.v. administration of AMTB reduced the frequency of rhythmic contractions in volume-loaded bladder and inhibited blood pressure and visceromotor reflex responses to bladder distention.

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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Identification of a natural compound, sesamin, as a novel TRPM8 antagonist with inhibitory effects on prostate adenocarcinoma.

Yutong Sui et al.

Fitoterapia, 145, 104631-104631 (2020-05-23)

Transient receptor potential melastatin 8 (TRPM8) is a calcium ion-permeable cation channel that is used as a prognostic marker and therapeutic target for different tumor types. To identify natural selective TRPM8 antagonists, we tested 158 traditional Chinese medicine (TCM) compounds

1,8-Cineole blocks voltage-gated L-type calcium channels in tracheal smooth muscle.

Átila Pereira-Gonçalves et al.

Pflugers Archiv : European journal of physiology, 470(12), 1803-1813 (2018-09-13)

1,8-Cineole is a cyclic monoterpenoid used in folk medicine for treatment of numerous respiratory diseases and other infections. 1,8-Cineole has anti-inflammatory, antioxidant, and myorelaxant effects, as well as low toxicity. In the present study, the effects of 1,8-cineole on contractility

Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels.

Kunsala T D S Yapa et al.

Life sciences, 198, 128-135 (2018-03-03)

To assess levels of the calcium permeable transient receptor potential cation channel, subfamily melastatin, member 8 (TRPM8) in breast cancer molecular subtypes and to assess the consequences of TRPM8 pharmacological inhibition with AMTB (an inhibitor of TRPM8) on breast cancer

TRPM8 channel augments T-cell activation and proliferation.

Tusar K Acharya et al.

Cell biology international, 45(1), 198-210 (2020-10-23)

The transient receptor potential melastatin 8 (TRPM8) is an ion channel that has been widely studied as a cold-sensitive nociceptor. However, its importance in nonneuronal cells is mostly unexplored. Here, we describe the presence and functional significance of endogenous TRPM8

Numer pozycji handlu globalnego

SKU	NUMER GTIN
SML0103-25MG	04061837076879
SML0103-5MG	04061837076886

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AMTB hydrate