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Merck

P7762

Poly-L-arginine hydrochloride

mol wt 15,000-70,000

Synonim(y):

L-Arginine homopolymer hydrochloride

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Wybierz wielkość

10 MG

352,00 zł

50 MG

1010,00 zł

100 MG

1550,00 zł

352,00 zł


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Informacje o tej pozycji

Numer CAS:
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:

Przejdź do

Pomoc techniczna
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Pozwól nam pomóc

form

powder

Quality Level

mol wt

15,000-70,000

color

white to off-white

application(s)

cell analysis

storage temp.

−20°C

SMILES string

Cl.NC(CCCNC(N)=N)C(O)=O

InChI

1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1

InChI key

PQEISBBDIRAKGR-LFELFHSZSA-N

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1 of 4

Ta pozycja
P3892P4663A2883
form

powder

form

powder or solid

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

color

white to off-white

color

white to off-white

color

white to off-white

color

white

mol wt

15,000-70,000

mol wt

>70,000

mol wt

5,000-15,000

mol wt

-

application(s)

cell analysis

application(s)

-

application(s)

cell analysis
detection

application(s)

-

General description

Poly-L-arginine hydrochloride (PLA) is a homopolyamino acid. PLA enhances membrane permeability compared to poly-L-lysine. It has applications as drug carrier, neuroprotective agent and in anticancer vaccines preparations. Peptide vaccines in conjugation with PLA promotes antigen-presenting cells (APCs) to generate T cell and elicit immunostimulant functionality.

Application

Poly-L-arginine hydrochloride has been used:
  • to generate complex with stimulatory RNA isRNA9.2 as in neutrophils
  • used in ribosomal RNA transfection into human monocytic THP-1 cells
  • for coating alginate capsule beads

Analysis Note

Molecular weight based on viscosity of precursor poly-L-ornithine. Also assayed by MALLS.
Contains 3% or less ornithine residue.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.
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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Factors influencing the mechanical stability of alginate beads applicable for immunoisolation of mammalian cells
Bhujbal SV, et al.
Journal of the Mechanical Behavior of Biomedical Materials, 37, 196-208 (2014)
RNA of Enterococcus faecalis strain EC-12 is a major component inducing interleukin-12 production from human monocytic cells
Nishibayashi R, et al.
PLoS ONE, 10(6), e0129806-e0129806 (2015)
Vaccination with poly-L-arginine as immunostimulant for peptide vaccines: induction of potent and long-lasting T-cell responses against cancer antigens
Mattner F, et al.
Cancer Research, 62(5), 1477-1480 (2002)
Neutrophils express distinct RNA receptors in a non-canonical way
Berger M, et al.
The Journal of Biological Chemistry, 287(23), 19409-19417 (2012)
Kotaro Sakamoto et al.
Frontiers in pharmacology, 12, 751587-751587 (2021-11-26)
Worldwide, more than 20 million people suffer from schizophrenia, but effective and definitive new therapeutic drugs/treatments have not been established. Vasoactive intestinal peptide receptor 2 (VIPR2) might be an attractive drug target for the treatment of schizophrenia because both preclinical and

Produkty

Montaż warstwa po warstwie oferuje wszechstronną metodę unieruchamiania cząsteczek funkcjonalnych w cienkich warstwach o kontrolowanej morfologii.

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

Recently, layer-by-layer (LbL) assembly has emerged as a versatile, gentle and, simple method for immobilization of functional molecules in an easily controllable thin film morphology.1,2 In this short review, we introduce recent advances in functional systems fabricated by using the mild, yet adaptable LbL technique.

Numer pozycji handlu globalnego

SKUNUMER GTIN
P7762-10MG04061832780498
P7762-100MG04061834397366
P7762-50MG04061832780504

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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