N7758

Naloxone hydrochloride dihydrate

≥98% (TLC and titration),  μ, κ, δ, and σ opioid receptor antagonist, powder

• Wzór empiryczny (zapis Hilla): C₁₉H₂₁NO₄ · HCl · 2H₂O
• Numer CAS: 51481-60-8
• Masa cząsteczkowa: 399.87
• NACRES: NA.77
• PubChem Substance ID: 24278050
• UNSPSC Code: 12352200
• MDL number: MFCD00150901
• Beilstein/REAXYS Number: 6260807
• Assay: ≥98% (TLC and titration)
• Form: powder

Właściwości

• Nazwa produktu: Naloxone hydrochloride dihydrate, ≥98% (TLC and titration), powder
• Quality Segment: 200
• assay: ≥98% (TLC and titration)
• form: powder
• optical activity: [α]25/D −178.6°, c = 2.5 in H₂O(lit.)
• color: white to off-white
• solubility: ethanol: 3.3 mg/mL, H₂O: 50 mg/mL
• storage temp.: 2-8°C
• SMILES string: O.O.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC=C
• InChI: 1S/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1
• InChI key: TXMZWEASFRBVKY-IOQDSZRYSA-N
• Gene Information: human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)

Opis

Application

Naloxone hydrochloride dihydrate has been used in:

• isotonic saline and injected subcutaneously into experimental rats to study its involvement with withdrawal syndrome in morphine-dependent rats
• as opioid receptor antagonist to examine the role of the endogenous opioid system in infantile amnesia for contextual fear
• as a reference neutral antagonist to define the maximum effect (Emax) of the system

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Disclaimer

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves