H4413

Hydroxyfasudil hydrochloride hydrate

≥98% (HPLC), solid

• Synonim(y): 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate
• Wzór empiryczny (zapis Hilla): C₁₄H₁₇N₃O₃S · HCl · xH₂O
• Numer CAS: 155558-32-0
• Masa cząsteczkowa: 343.83 (anhydrous basis)
• NACRES: NA.77
• PubChem Substance ID: 24724499
• UNSPSC Code: 12352200
• MDL number: MFCD06411567
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100

Właściwości

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• composition: The two peaks show the equilibrim between the two tautomers
• color: white
• solubility: H₂O: >5 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl[H].Oc1nccc2c(cccc12)S(=O)(=O)N3CCCNCC3
• InChI: 1S/C14H17N3O3S.ClH/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17;/h1,3-5,7,15H,2,6,8-10H2,(H,16,18);1H
• InChI key: XWWFOUVDVJGNNG-UHFFFAOYSA-N

Opis

Application

Hydroxyfasudil hydrochloride hydrate has been used as a ROCK inhibitor to study the role of different signaling pathways in the chemokines CCL19 and CCL21, the CCR7 ligands mediated effects on migratory and prosurvival, in CLL cells.

Biochem/physiol Actions

Hydroxyfasudil possessantispastic action. It is an active metabolite of fasudil. Hydroxyfasudil might enhance the dynamics of blood flow and prevent damage caused by neutrophils.

Rho-kinase inhibitor.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves