G5131

Guanosine 5′-diphospho-D-mannose sodium salt from Saccharomyces cerevisiae

Type I, ≥97% (HPLC)

• Synonim(y): GDP-Man, GDP-mannose
• Wzór liniowy: C₁₆H₂₃N₅O₁₆P₂Na₂
• Numer CAS: 103301-73-1
• Masa cząsteczkowa: 649.30
• MDL number: MFCD00070120
• UNSPSC Code: 41106305
• PubChem Substance ID: 24895196
• NACRES: NA.51
• Assay: ≥97% (HPLC)

Właściwości

• type: Type I
• Quality Segment: 200
• assay: ≥97% (HPLC)
• storage temp.: −20°C
• SMILES string: [Na].NC1=NC(=O)c2ncn(C3OC(COP(O)(=O)OP(O)(=O)OC4OC(CO)C(O)C(O)C4O)C(O)C3O)c2N1
• InChI: 1S/C16H25N5O16P2.Na.H/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15;;/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28);;
• InChI key: MEXITZOHWLXZKR-UHFFFAOYSA-N

Opis

General description

Guanosine 5′-diphospho-D-mannose (GDP-D-mannose) is present in high cytosolic levels in Saccharomyces cerevisiae. It is crucial for protein mannosylation.[1] GDP-D-mannose is an important precursor to produce GDP-l-fucose.[1]

Application

Guanosine 5′-diphospho-D-mannose sodium salt from Saccharomyces cerevisiae has been used as a nucleotide sugar in transglycosylation enzymatic assay and hydrolysis based catalytic reactions with S-glycosyltransferases (SunS).[2]

Guanosine 5′-diphospho-D-mannose sodium salt has been used as a component of ATP regeneration system for in vitro vesicle formation from Saccharomyces cerevisiae microsomes. It has also been used as a component of the buffer for mannosyl transferase activity assay.

Biochem/physiol Actions

Guanosine diphosphate mannose (GDP-mannose) is a nucleotide sugar substrate for glycosyltransferase (mannosylation) reactions mediated by mannosyltransferases.[3]

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable