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D3506

Sigma-Aldrich

Sodium diethyldithiocarbamate trihydrate

Synonim(y):

Cupral, Diethyldithiocarbamic acid sodium salt

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About This Item

Wzór liniowy:
(C2H5)2NCSSNa · 3H2O
Numer CAS:
20624-25-3
Masa cząsteczkowa:
225.31
Beilstein:
3920507
Numer WE:
205-710-6
Numer MDL:
MFCD00150617
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
57654092
NACRES:
NA.77

gęstość pary

5.9 (vs air)

Próba

≥97% (perchloric acid titration)

Postać

powder or crystals

mp

95-98.5 °C (lit.)

rozpuszczalność

water: 1 g/10 mL, slightly hazy

temp. przechowywania

room temp

ciąg SMILES

[H]O[H].[H]O[H].[H]O[H].CCN(CC)C(=S)S[Na]

InChI

1S/C5H11NS2.Na.3H2O/c1-3-6(4-2)5(7)8;;;;/h3-4H2,1-2H3,(H,7,8);;3*1H2/q;+1;;;/p-1

Klucz InChI

WWGXHTXOZKVJDN-UHFFFAOYSA-M

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Zastosowanie

Spin trap used in conjunction with Fe2+ to detect NO in brain, kidney, liver, and other tissues. Simultaneous direct measurement of NO* and pO2 has been reported. A copper chelator, it has been used to quantitate copper in biological materials by ESR and is an inhibitor of superoxide dismutase, ascorbate oxidase, and other enzymes.

Działania biochem./fizjol.

Inhibits induction of macrophage nitric oxide synthase.

Cechy i korzyści

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Dopamine, Norepinephrine and Epinephrine Synthesis page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Przestroga

May form insoluble oxidation products in storage. Sensitivity in colorimetric copper determination not usually affected.
This page may contain text that has been machine translated.

Piktogramy

CorrosionExclamation mark
GHS05,GHS07

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H302,H315,H318

Klasyfikacja zagrożeń

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

dust mask type N95 (US), Eyeshields, Gloves

Certyfikaty analizy (CoA)

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Sodium dimethyldithiocarbamate solution ~40% in H2O

Sigma-Aldrich

71513

Sodium dimethyldithiocarbamate solution

Pentylmagnesium bromide solution 2.0 M in diethyl ether

Sigma-Aldrich

290998

Pentylmagnesium bromide solution

Y Suzuki et al.
Free radical research, 28(3), 293-299 (1998-08-04)
To detect nitric oxide (NO) in the rat brain during lipopolysaccharide (LPS)-induced sepsis, electron paramagnetic resonance (EPR) was employed with the NO trapping technique, using an iron and N,N-diethyldithiocarbamate (DETC) complex. An X-band (about 9.5 GHz) EPR system detected a
Jonathan H Pérez et al.
The Journal of experimental biology, 223(Pt 1) (2019-12-05)
The hypothalamic-pituitary-adrenal (HPA) axis is under complex regulatory control at multiple levels. Enzymatic regulation plays an important role in both circulating levels of glucocorticoids and target tissue exposure. Three key enzyme pathways are responsible for the immediate control of glucocorticoids.
Muriel Cuendet et al.
Nature protocols, 1(4), 1915-1921 (2007-05-10)
The cyclooxygenase (COX) reaction can be monitored by measurement of oxygen consumption, peroxidase co-substrate oxidation or prostaglandin (PG) detection. This protocol describes a procedure measuring cyclooxygenase activity by quantifying PGE2 produced by enzymatic conversion of arachidonic acid, in the presence
Tianhui Liu et al.
British journal of pharmacology, 175(24), 4480-4495 (2018-09-29)
Diethyldithiocarbamate (DDC) is a major metabolite of disulfiram that is a potential drug for alcoholism treatment. In the present study, we attempted to explore the possible effect of DDC on non-alcoholic fatty liver disease (NAFLD) and related fibrosis in vivo.
Gaurav Agrahari et al.
The Journal of investigative dermatology, 140(3), 656-665 (2019-08-30)
The expressions of LL-37 and KLK-5 were found to be altered in various dermatoses, including atopic dermatitis, psoriasis, and rosacea. However, the downstream inflammatory effect of LL-37 and KLK-5 is not as well studied. In addition, there is little high-quality
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