The stability of this product in solution for extended periods has not been determined. Stock solutions stored in aliquots at -70°C are stable up to 6 months. Stock solutions may also be stored at -20°C, however no time frame has been established.
C1768
Cytarabine
≥90% (HPLC), crystalline, DNA replication inhibitor
Synonim(y):
(β-D-Arabinofuranosyl)cytosine, Ara-C, Arabinocytidine, Arabinosylcytosine, Cytarabine, Cytosine arabinoside
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Wybierz wielkość
100 MG
290,00 zł
500 MG
643,00 zł
1 G
889,00 zł
5 G
3550,00 zł
290,00 zł
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C9H13N3O5
Numer CAS:
Masa cząsteczkowa:
243.22
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
205-705-9
MDL number:
Beilstein/REAXYS Number:
89175
Przejdź do
Pomoc techniczna
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Pozwól nam pomócNazwa produktu
Cytosine β-D-arabinofuranoside, crystalline, ≥90% (HPLC)
InChI key
UHDGCWIWMRVCDJ-CCXZUQQUSA-N
InChI
1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1
SMILES string
NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O
assay
≥90% (HPLC)
form
crystalline
storage temp.
2-8°C
Quality Level
Gene Information
human ... POLA1(5422), POLA2(23649), POLB(5423), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558)
mouse ... Cda(72269)
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Powiązane kategorie
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Ta pozycja | |||
|---|---|---|---|
| form crystalline | form - | form - | form crystalline |
| assay ≥90% (HPLC) | assay - | assay - | assay ≥99% (HPLC) |
| Quality Level 200 | Quality Level 300 | Quality Level - | Quality Level 200 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| Gene Information human ... POLA1(5422), POLA2(23649), POLB(5423), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558) | Gene Information human ... POLA1(5422), POLA2(23649), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558) | Gene Information human ... POLA1(5422), POLA2(23649), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558) | Gene Information human ... POLA1(5422), POLA2(23649), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558) |
Biochem/physiol Actions
Ara-C incorporates into DNA and inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation; does not inhibit RNA synthesis. Anti-leukemia agent.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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Danger
hcodes
Hazard Classifications
Muta. 1B - Repr. 2
Klasa składowania
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
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Produkty
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
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How long could a solution of 2uM be stable at -80C? Would this storage help the aliquots last longer than a year at -20C?
1 answer-
Helpful?
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Hello, does the freeze-thaw cycle affect the potency or stability of cytarabine?
1 answer-
The freeze-thaw stability of this material in solution has not been determined. However, Cold Spring Harbor Protocols suggests solutions are stable for several weeks when refrigerated. For long term storage, store solutions in working aliquots at −20°C . Please see the link below to review this information:
https://cshprotocols.cshlp.org/content/2008/12/pdb.rec11555.full?text_only=trueHelpful?
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Does cytoine beta d arabinofuranoside (Arac) solution filterable by .22um filter ,, is it good idea to filter ara c
1 answer-
This product is soluble in water at 50 mg/mL and may be filter sterilized. It is recommended to use a low protein binding filter membrane, such as PES, to prevent product retention in the filter. Solution stability has not been determined, however, Cold Spring Harbor protocols suggest that the filtered stock solution may be stored refrigerated or frozen.
See the link below to review:
https://cshprotocols.cshlp.org/content/2008/12/pdb.rec11555.full?text_only=trueHelpful?
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Active Filters
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