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681667

Wnt Agonist II, SKL2001

The Wnt Agonist II, SKL2001 controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Biochemicals applications.

Synonim(y):

Wnt Agonist II, SKL2001, 5-(Furan-2-yl)-N-(3-(1H-imidazol-1-yl)propyl)-1,2-oxazole-3-carboxamide, Wnt Pathway Activator VII

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Gabaryty przesyłkiSKUDostępnośćCena netto
25 mg

Przewidywany termin wysyłki02 czerwca 2026zKuehne + Nagel Sp. z o.o.

1100,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C14H14N4O3
Numer CAS:
909089-13-0
Masa cząsteczkowa:
286.29
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD14733081
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

1100,00 zł

Przewidywany termin wysyłki02 czerwca 2026Szczegóły

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Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

pink-red

solubility

DMSO: 100 mg/mL, clear, red

shipped in

ambient

storage temp.

2-8°C

SMILES string

O=C(C1=NOC(C2=CC=CO2)=C1)NCCCN3C=NC=C3

InChI

1S/C14H14N4O3/c19-14(16-4-2-6-18-7-5-15-10-18)11-9-13(21-17-11)12-3-1-8-20-12/h1,3,5,7-10H,2,4,6H2,(H,16,19)

InChI key

PQXINDBPUDNMPE-UHFFFAOYSA-N

General description

A cell-permeable imidazolyl-isoxazolamide compound that upregulates β-catenin-regulated transcription (CRT; Effective conc. 10 - 40 µM) by blocking/disrupting β-catenin and Axin interaction, thereby preventing β-catenin phosphorylation (Ser33/Ser37/Thr41/Ser45) and proteasomal degradation, without affecting the activities of GSK-3α/β or 18 other kinases (≤8.5% inhibition by 10 µM SKL2001). Wnt pathway activation by SKL2001 is shown to effectively promote osteoblastogenesis in both human and murine mesenchymal cultures (10 to 40 µM) as well as suppress MDI- (dexamethasone and insulin) stimulated adipogenesis of murine 3T3-L1 preadipocytes (5 to 30 µM).

Packaging

Packaged under inert gas

Other Notes

Gwak, J., et al. 2012. Cell Res.22, 237.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)
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Ta pozycja
681671681665681668
Wnt Agonist II, SKL2001 The Wnt Agonist II, SKL2001 controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Biochemicals applications.

Sigma-Aldrich

681667

Wnt Agonist II, SKL2001

Wnt Antagonist II, IWP-2 The Wnt Antagonist II, IWP-2, also referenced under CAS 686770-61-6, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

681671

Wnt Antagonist II, IWP-2

Wnt Agonist The Wnt Agonist, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

681665

Wnt Agonist

Wnt Synergist, QS11 A cell-permeable purine compound that binds ARFGAPs (Kd = 364 and 620 nM for AMAP1 and ARFGAP1, respectively) and acts as a broad specificity ARFGAPs inhibitor (GTPase activating proteins of ADP-ribosylation factor).

Sigma-Aldrich

681668

Wnt Synergist, QS11

form

solid

form

solid

form

solid (sticky)

form

solid

assay

≥95% (HPLC)

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certyfikaty analizy (CoA)

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Odwiedź Bibliotekę dokumentów

Xian Lu et al.
Molecular and clinical oncology, 19(4), 77-77 (2023-09-18)
Wnt/β-catenin signaling is associated with epithelial-mesenchymal transformation (EMT), which serves an important role in hepatocellular carcinoma (HCC) invasion and metastasis. Frankincense and myrrh (FM) are antitumor agents commonly used in clinical practice. The present study aimed to investigate the effect
Suzanne E Eldridge et al.
Science translational medicine, 12(559) (2020-09-04)
Cartilage loss leads to osteoarthritis, the most common cause of disability for which there is no cure. Cartilage regeneration, therefore, is a priority in medicine. We report that agrin is a potent chondrogenic factor and that a single intraarticular administration
Camille Cohen et al.
Nature communications, 15(1), 743-743 (2024-01-26)
Chronic kidney disease (CKD) is a public health problem driven by myofibroblast accumulation, leading to interstitial fibrosis. Heterogeneity is a recently recognized characteristic in kidney fibroblasts in CKD, but the role of different populations is still unclear. Here, we characterize

Numer pozycji handlu globalnego

SKUNUMER GTIN
681667-25MG04055977260250

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