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Dokumenty

654380

Sigma-Aldrich

Tunicamycin

from Strepomyces lysosuperficus, ≥98% (A+B+C+D, HPLC), powder, N-acetylglucosamine transferase, Calbiochem

Synonim(y):

Tunicamycin, Streptomyces lysosuperficus

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About This Item

Wzór empiryczny (zapis Hilla):
C39H64N4O16
Numer CAS:
11089-65-9
Masa cząsteczkowa:
844.94
Numer MDL:
MFCD00065709
Kod UNSPSC:
12352200
NACRES:
NA.77

product name

Tunicamycin, Streptomyces lysosuperficus,

opis

Tunicamycin, Streptomyces lysosuperficus

Poziom jakości

200

Próba

≥98% (A+B+C+D, HPLC)

Postać

powder

producent / nazwa handlowa

Calbiochem®

rozpuszczalność

DMSO: 10 mg/mL
DMF: soluble
pyridine: soluble

Warunki transportu

ambient

temp. przechowywania

2-8°C

InChI

1S/C30H46N4O16/c1-11(2)5-4-6-16(38)32-19-23(43)20(40)14(47-29(19)50-28-18(31-12(3)36)22(42)21(41)15(10-35)48-28)9-13(37)26-24(44)25(45)27(49-26)34-8-7-17(39)33-30(34)46/h4,6-8,11,13-15,18-29,35,37,40-45H,5,9-10H2,1-3H3,(H,31,36)(H,32,38)(H,33,39,46)/b6-4+/t13?,14-,15-,18-,19-,20+,21-,22-,23-,24+,25-,26-,27-,28-,29-/m1/s1

Klucz InChI

ZHSGGJXRNHWHRS-PEALBESXSA-N

Opis ogólny

A nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca2+ mobilization in cells. Also available as a 25 mM solution in DMSO (Cat. No. 504570).
A nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca2+ mobilization in cells.

Działania biochem./fizjol.

Primary Target
N-linked glycosylation
Secondary Target
thrombin-induced Ca2+ mobilization in cells

Ostrzeżenie

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

Uwaga dotycząca przygotowania

Aqueous solutions can be prepared from DMSO stock solutions by diluting in H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0.

Rekonstytucja

Aqueous solutions can be prepared from stock solutions in DMSO by diluting with H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0 (preferably >8.0).
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

Inne uwagi

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Tordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857.
Price, B.D., et al. 1992. J. Cell Physiol.152, 545.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Piktogramy

Skull and crossbones
GHS06

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H300

Zwroty wskazujące środki ostrożności

P264 - P270 - P301 + P310 - P405 - P501

Klasyfikacja zagrożeń

Acute Tox. 1 Oral

Kod klasy składowania

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

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