475914

Nystatin

from Streptomyces noursei, ≥95% (sum of two peaks, HPLC), solid, sodium ionoph, Calbiochem^®

• Synonim(y): Nystatin, Streptomyces noursei, Mycostatin
• Wzór empiryczny (zapis Hilla): C₄₇H₇₅NO₁₇
• Numer CAS: 1400-61-9
• Masa cząsteczkowa: 926.09
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD25541651
• Assay: ≥95% (sum of two peaks, HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Właściwości

• Nazwa produktu: Nystatin, Streptomyces noursei, A polyene antifungal antibiotic effective against yeast and mycoplasma.
• Quality Segment: 100
• description: Merck USA index - 14, 6736
• assay: ≥95% (sum of two peaks, HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: off-white to yellow
• solubility: DMSO: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: N[C@@H]1[C@@H]([C@H](O[C@@H]([C@H]1O)C)OC2CC3O[C@@](CC(C3C(=O)O)O)(CC(C(CCC(CC(CC(CC(=O)O[C@H]([C@@H]([C@@H]([C@H](\C=C\C=C\CC\C=C\C=C\C=C\C=C\2)C)O)C)C)O)O)O)O)O)O)O
• InChI: 1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31?,32?,33?,34?,35?,36?,37?,38?,40?,41-,42+,43+,44-,46+,47+/m0/s1
• InChI key: VQOXZBDYSJBXMA-RKEBNKJGSA-N

Opis

General description

A polyene antifungal antibiotic effective against yeast and mycoplasma. Induces loss of low molecular weight substances from cells with low selectivity. A cation selective ionophore that exhibits selectivity for Na⁺. Increases the activity of the Na⁺-K⁺ pump. Suggested concentration is 50 µg/ml.

Biochem/physiol Actions

Potency: ≥3000 units/mg (anhydrous).

Other Notes

Gruwel, M.L., et al. 1995. Am J. Physiol.268, H351.
Opekarova, M., and Tanner, W. 1994. FEBS Lett. 360, 46.
Stoos, B.A., et al. 1994. J. Am. Soc. Nephrol.4, 1855.
Skolink, P.R., et al. 1989. J. Infect. Dis.160, 1056.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable