203350

Blasticidin S hydrochloride

from Streptomyces griseochromogenes, ≥98% (HPLC), powder, protein syntheis inhibitor, Calbiochem^®

• Synonim(y): Blasticidin S, Hydrochloride, Streptomyces griseochromogenes
• Wzór empiryczny (zapis Hilla): C₁₇H₂₆N₈O₅ · xHCl
• Numer CAS: 3513-03-9
• Masa cząsteczkowa: 422.44 (free base basis)
• UNSPSC Code: 51286700
• NACRES: NA.77
• MDL number: MFCD02091640
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100
• Storage condition: OK to freeze, desiccated (hygroscopic)

Właściwości

• Nazwa produktu: Blasticidin S, chlorowodorek, Streptomyces griseochromogenes,
• assay: ≥98% (HPLC)
• Quality Level: 100
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• color: white to off-white
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: Cl.N2(C=CC(=NC2=O)N)[C@@H]1O[C@@H]([C@H](C=C1)NC(=O)C[C@@H](N)CCN(C)\C(=N\[H])\N)C(=O)O
• InChI: 1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H/t9-,10-,13+,14-;/m0./s1
• InChI key: YQXYQOXRCNEATG-NMQKUDMSSA-N

Opis

General description

Nucleoside antibiotic that specifically inhibits protein synthesis in both prokaryotes and eukaryotes. Suitable for selection of cells carrying plasmids conferring blasticidin resistance. Blasticidin resistance is conferred by the blasticidin S deaminase genes (bsr from Bacillus cereus or BSD from Aspergillus terreus), whose products convert blasticidin S to a non-toxic deaminohydroxy derivative.

Biochem/physiol Actions

Primary Target
protein synthesis

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions (pH ≤7) are stable for up to 1 year at -20°C. Avoid alkaline pH. Do not subject to freeze/thaw cycles; upon thawing any aliquots, discard the unused portion.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Kimura, M., et al. 1994. Biochim. Biophys. Acta1219, 653.
Kimura, M., et al. 1994, Mol. Gen. Genet.242, 121.
Kojima, N., et al. 1994. J. Biol. Chem.269, 30451.
Kudo, T., et al. 1994. J. Immunol. Methods177, 17.
Sutoh, K. 1993. Plasmid30, 150.
Izumi, M., et al. 1991. Exp. Cell Res.197, 229.
Yamaguchi, H., et al. 1965. J. Biol. Chem.57, 667.
Takeuchi, S., et al. 1958. J. Antibiot.11, 1.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic (H)

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Informacja o środkach bezpieczeństwa

• pictograms: GHS06
• signalword: Danger
• hcodes: H300
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 1 Oral
• Klasa składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable