573108-M

STAT5 Inhibitor

The STAT5 Inhibitor, also referenced under CAS 285986-31-4, controls the biological activity of STAT5.

• Synonim(y): STAT5 Inhibitor, Nʹ-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
• Wzór empiryczny (zapis Hilla): C₁₆H₁₁N₃O₃
• Numer CAS: 285986-31-4
• Masa cząsteczkowa: 293.28
• MDL number: MFCD00124694
• UNSPSC Code: 12352200
• NACRES: NA.28
• Assay: ≥97% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Właściwości

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: DMSO: 25 mg/mL
• storage temp.: 2-8°C
• SMILES string: N(\N=C\c2[c](c3c([o]c2)cccc3)=O)C(=O)c1cnccc1
• InChI key: DAVIKTBRCQWOGT-GIJQJNRQSA-N

Opis

General description

A cell-permeable nonpeptidic nicotinoyl hydrazone compound that selectively targets the SH2 domain of STAT5 (IC₅₀ = 47 µM against STAT5b SH2 domain EPO peptide binding activity), while exhibiting much less effect towards the SH2 domain of STAT1, STAT3, or Lck (IC₅₀ >500 µM). Shown to block STAT5/STAT5 DNA binding activity in K562 nuclear extract and inhibit IFN-α-stimulated STAT5, but not STAT1 or STAT3, tyrosine phosphorylation in Daudi cells.

Other Notes

Muller, J., et al. 2008. ChemBioChem9, 723.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable