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528116

Inhibitor PI 3-Kα VIII

The PI 3-Kα Inhibitor VIII controls the biological activity of PI 3-Kα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonim(y):

N-((1E)-(6-bromoimidazo[1,2-a]pirydyn-3-ylo)metyleno)-Nʹ-metylo-Nʹʹ-(2-metylo-5-nitrobenzeno)sulfonohydrazyd, HCl, PIK-75, inhibitor PI 3-K VIII

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Gabaryty przesyłkiSKUDostępnośćCena netto
250 mg

Przewidywany termin wysyłki25 maja 2026zKuehne + Nagel Sp. z o.o.

69 750,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C16H14BrN5O4S · 2H2O · xHCl
Numer CAS:
372196-77-5
Masa cząsteczkowa:
488.31 (free base basis)
MDL number:
MFCD12546130
UNSPSC Code:
12352200
NACRES:
NA.28
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light

69 750,00 zł

Przewidywany termin wysyłki25 maja 2026Szczegóły

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Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

pale yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(N(\N=C\c2[n]3c(nc2)ccc(c3)Br)C)c1c(ccc(c1)[N+](=O)[O-])C.Cl

InChI

1S/C16H14BrN5O4S.ClH/c1-11-3-5-13(22(23)24)7-15(11)27(25,26)20(2)19-9-14-8-18-16-6-4-12(17)10-21(14)16;/h3-10H,1-2H3;1H/b19-9+;

InChI key

VOUDEIAYNKZQKM-MYHMWQFYSA-N

General description

Przepuszczalny dla komórek związek imidazopirydynowy, który działa jako wysoce silny i kompetytywny względem ATP inhibitor DNA-PK i selektywny inhibitor PI3-K p110α (IC50 = 0,3, 40, 100 i 850 nM odpowiednio dla p110α, p110γ, PI 3-K C2β i p110β). Wykazano, że skutecznie blokuje komórkową sygnalizację PI3-K/Akt i hamuje wzrost guza zarówno in vitro (IC50 ≤58 nM w hodowlach MCF7, MCF7 ADR-res, HeLa, A375 i A549), jak i u myszy in vivo (62% zahamowanie ksenoprzeszczepu HeLa w ciągu 2 tygodni, 50 mg/kg/dzień, i.p.).

Packaging

Pakowane w atmosferze gazu obojętnego

Preparation Note

Po rekonstytucji, podzielić i zamrozić (-20°C). Roztwory podstawowe są stabilne przez okres do 3 miesięcy w temperaturze -20°C.

Other Notes

Kim, S., et al. 2007. Blood 110, 4206.
Hayakawa, M., et al. 2007. Bioorg. Med. Chem.15, 5837.
Knight, Z.A., et al. 2007. Cell125, 733.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

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Ta pozycja
528111528108528106
PI 3-Kα Inhibitor VIII The PI 3-Kα Inhibitor VIII controls the biological activity of PI 3-Kα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

528116

PI 3-Kα Inhibitor VIII

PI 3-Kα Inhibitor IV The PI 3-Kα Inhibitor IV, also referenced under CAS 1188890-32-5, controls the biological activity of PI 3-Kα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

528111

PI 3-Kα Inhibitor IV

PI 3-Kγ Inhibitor II The PI 3-Kγ Inhibitor II, also referenced under CAS 648449-76-7, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

528108

PI 3-Kγ Inhibitor II

PI 3-Kγ Inhibitor The PI 3-Kγ Inhibitor, also referenced under CAS 648450-29-7, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

528106

PI 3-Kγ Inhibitor

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥90% (HPLC)

form

solid

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light, desiccated (hygroscopic)

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

Klasa składowania

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Powiązane treści

Human Kinome & InhibitorSelect™ Libraries

Human Kinome Poster: The InhibitorSelect™ Protein Kinase Inhibitor Libraries provide broad coverage of the human kinome as shown here. The depicted human kinome dendrogram of 518 kinases are classified into five broad groups, 90 families, and 145 subfamilies. Inhibitor coverage was assigned based upon published data related to potency (IC50, EC50, Kd, etc.) for individual kinases harvested from the literature. Colored dots denote which library contains an inhibitor with demonstrated potent activity against the designated kinase and do not necessarily reflect known specificity of the inhibitor. Coverage of lipid and atypical kinases are depicted as a separate dendrogram. As shown, Calbiochem® Protein Kinase Inhibitor Libraries cover all major kinase families including TK, CMGC, CAMK, AGC, CK1, STE, TKL, as well as Lipid or Atypical kinase families.

Soochong Kim et al.
Blood, 110(13), 4206-4213 (2007-09-11)
Platelets release insulin-like growth factor-1 (IGF-1) from alpha granules upon activation. We have investigated the regulation of IGF-1 in G(i)-dependent pathways leading to Akt activation and the role of IGF-1 in platelet activation. IGF-1 alone failed to induce platelet aggregation
Masahiko Hayakawa et al.
Bioorganic & medicinal chemistry, 15(17), 5837-5844 (2007-07-03)
We have previously reported the imidazo[1,2-a]pyridine derivative 4 as a novel p110alpha inhibitor; however, although 4 is a potent inhibitor of p110alpha enzymatic activity and tumor cell proliferation in vitro, it is unstable in solution and ineffective in vivo. To
Zachary A Knight et al.
Cell, 125(4), 733-747 (2006-05-02)
Phosphoinositide 3-kinases (PI3-Ks) are an important emerging class of drug targets, but the unique roles of PI3-K isoforms remain poorly defined. We describe here an approach to pharmacologically interrogate the PI3-K family. A chemically diverse panel of PI3-K inhibitors was
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Numer pozycji handlu globalnego

SKUNUMER GTIN
528116-250MG04055977196986
528116-5MG04055977196993

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