1674004

Tretynoina

United States Pharmacopeia (USP) Reference Standard

• Synonim(y): Retinoic acid, ATRA, Tretinoin, Vitamin A acid, all-trans-Retinoic acid
• Wzór empiryczny (zapis Hilla): C₂₀H₂₈O₂
• Numer CAS: 302-79-4
• Masa cząsteczkowa: 300.44
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329751371
• MDL number: MFCD00001551
• Beilstein/REAXYS Number: 2057223

Właściwości

• grade: pharmaceutical primary standard
• agency: USP
• API family: tretinoin
• manufacturer/tradename: USP
• mp: 180-181 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1
• InChI: 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
• InChI key: SHGAZHPCJJPHSC-YCNIQYBTSA-N
• Gene Information: human ... RARA(5914), RARB(5915), RARG(5916)

Opis

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Wzorzec referencyjny Tretinoin USP, przeznaczony do stosowania w określonych testach jakości i oznaczeniach, jak określono w kompendiach USP. Również do użytku z monografiami USP, takimi jak:

• Tretinoin Cream
• Tretinoin Gel
• Tretinoin roztwór do stosowania miejscowego
• Izotretynoina
• Kapsułki izotretynoiny
• Acitretin

Biochem/physiol Actions

all−trans−Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.

Ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR); primes embryonic stem cells to become neurons.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08,GHS07,GHS09
• signalword: Danger
• hcodes: H302,H315,H360FD,H410
• pcodes: P202 - P264 - P273 - P301 + P312 - P302 + P352 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• flash_point_f: Not applicable
• flash_point_c: Not applicable