1674004

Tretinoin

United States Pharmacopeia (USP) Reference Standard

• Synonim(y): Retinoic acid, ATRA, Tretinoin, Vitamin A acid, all-trans-Retinoic acid
• Wzór empiryczny (zapis Hilla): C₂₀H₂₈O₂
• Numer CAS: 302-79-4
• Masa cząsteczkowa: 300.44
• Beilstein: 2057223
• Numer MDL: MFCD00001551
• Kod UNSPSC: 41116107
• Identyfikator substancji w PubChem: 329751371
• NACRES: NA.24

Właściwości

• klasa czystości: pharmaceutical primary standard
• rodzina API: tretinoin
• producent / nazwa handlowa: USP
• mp: 180-181 °C (lit.)
• Zastosowanie: pharmaceutical (small molecule)
• format: neat
• ciąg SMILES: CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1
• InChI: 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
• Klucz InChI: SHGAZHPCJJPHSC-YCNIQYBTSA-N
• informacje o genach: human ... RARA(5914) , RARB(5915) , RARG(5916)

Opis

Opis ogólny

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Zastosowanie

Tretinoin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Tretinoin Cream
• Tretinoin Gel
• Tretinoin Topical Solution
• Isotretinoin
• Isotretinoin Capsules
• Acitretin

Działania biochem./fizjol.

all−trans−Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.

Komentarz do analizy

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Inne uwagi

Sales restrictions may apply.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS07,GHS09
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H302,H315,H360FD,H410
• Zwroty wskazujące środki ostrożności: P202 - P264 - P273 - P301 + P312 - P302 + P352 - P308 + P313
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2
• Kod klasy składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable