T1850000

Tretinoin

European Pharmacopoeia (EP) Reference Standard

• Synonim(y): Retinoic acid, ATRA, Tretinoin, Vitamin A acid, all-trans-Retinoic acid
• Wzór empiryczny (zapis Hilla): C₂₀H₂₈O₂
• Numer CAS: 302-79-4
• Masa cząsteczkowa: 300.44
• Beilstein: 2057223
• Numer MDL: MFCD00001551
• Kod UNSPSC: 41116107
• Identyfikator substancji w PubChem: 329826691
• NACRES: NA.24

Właściwości

• pochodzenie biologiczne: synthetic
• klasa czystości: pharmaceutical primary standard
• agency: EP
• rodzina API: tretinoin
• Formularz: solid
• producent / nazwa handlowa: EDQM
• metody: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• mp: 180-181 °C (lit.)
• Zastosowanie: pharmaceutical (small molecule)
• Format: neat
• temp. przechowywania: 2-8°C
• ciąg SMILES: CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1
• InChI: 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
• Klucz InChI: SHGAZHPCJJPHSC-YCNIQYBTSA-N
• informacje o genach: human ... RARA(5914) , RARB(5915) , RARG(5916)

Opis

Opis ogólny

This product is provided as delivered and specified by the issuing pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the authority of the issuing pharmacopoeia. For further information and support please go to the website of the issuing pharmacopoeia.

Tretinoin is a medication used to treat a variety of skin conditions such as photodamaged skin, acne, etc. It is used as an anti-aging product and also as an oral treatment for leukemia.[1]

Zastosowanie

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

Działania biochem./fizjol.

all−trans−Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.

Ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR); primes embryonic stem cells to become neurons.

Opakowanie

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Inne uwagi

Sales restrictions may apply.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS07,GHS09
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H302,H315,H360FD,H410
• Zwroty wskazujące środki ostrożności: P202 - P264 - P273 - P301 + P312 - P302 + P352 - P308 + P313
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2
• Kod klasy składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable