T6397

3,3′,5-Triiodo-L-thyronine sodium salt

powder, BioReagent, suitable for cell culture

• Synonim(y): Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T₃
• Wzór empiryczny (zapis Hilla): C₁₅H₁₁I₃NNaO₄
• Numer CAS: 55-06-1
• Masa cząsteczkowa: 672.96
• Beilstein: 8179867
• Numer WE: 200-223-5
• Numer MDL: MFCD00002594
• Kod UNSPSC: 12352209
• Identyfikator substancji w PubChem: 24900372
• NACRES: NA.77

Właściwości

• pochodzenie biologiczne: synthetic
• Poziom jakości: 200
• linia produktu: BioReagent
• Próba: ≥95%
• Postać: powder
• siła działania: 0.02-50 ng/mL (lit.)
• metody: cell culture | mammalian: suitable
• rozpuszczalność: ethanol/1 M HCl (4:1): 10 mg/mL, clear, colorless to yellow
• Warunki transportu: ambient
• temp. przechowywania: −20°C
• ciąg SMILES: [Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O
• InChI: 1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1
• Klucz InChI: SBXXSUDPJJJJLC-YDALLXLXSA-M
• informacje o genach: human ... THRA(7067) , THRB(7068) ; rat ... Thra(81812) , Thrb(24831)

Opis

Opis ogólny

3,3′,5′-Triiodo-L-thyronine (T₃) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T₄) serves as a precursor for T₃ and is generated in extrathyroidal tissues.

Zastosowanie

3,3′,5-Triiodo-L-thyronine sodium salt has been used for inducing thyroid hormone manipulations in mice. It has also been used In cell culturing of hippocampal, retinal, proximal tubule and glomerular explant.

Działania biochem./fizjol.

3,3′,5′-Triiodo-L-thyronine (T₃) increases the rates of protein synthesis, stimulates the breakdown of cholesterol and effects embryonic development. In cell culture, T₃ regulates cell differentiation and protein expression. The interaction of T₃ with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T₃ hormone is reduced in hypothyroidism.

Postać fizyczna

powder-20 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Rekonstytucja

To prepare 20 μg/ml stock solution: add 1ml 1N NaOH per mg 3,3′, 5-triiodo-L-thyronine; gently swirl to dissolve. To this, add 49 ml sterile medium per ml 1N NaOH added.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)