The solubility in PBS has not been evaluated, and additional stability studies following reconstitution have not been conducted. According to the datasheet, storage should be in a tightly sealed container at room temperature, and the product is soluble in water at 89 mg/ml. More information can be found in the document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/363/806/r121dat.pdf. According to established guidelines, the stock solution should be stored as follows: at -80 °C, it is recommended to use the solution within 6 months; at -20 °C, it should be used within 1 month.
R121
S(−)-Raclopride (+)-tartrate salt
>97%, Dopamine D2 receptor antagonist, solid
Synonim(y):
3,5-Dichloro-N-(1-ethylpyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxybenzamide (+)-tartrate salt
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Wybierz wielkość
25 MG
798,00 zł
100 MG
2390,00 zł
798,00 zł
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C15H20Cl2N2O3 · C4H6O6
Numer CAS:
Masa cząsteczkowa:
497.32
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Przejdź do
Pomoc techniczna
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Pozwól nam pomócNazwa produktu
S(−)-Raclopride (+)-tartrate salt, >97%, solid
Quality Level
assay
>97%
form
solid
color
white
solubility
H2O: 89 mg/mL
SMILES string
O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCN1CCC[C@H]1CNC(=O)c2c(O)c(Cl)cc(Cl)c2OC
InChI
1S/C15H20Cl2N2O3.C4H6O6/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2;5-1(3(7)8)2(6)4(9)10/h7,9,20H,3-6,8H2,1-2H3,(H,18,21);1-2,5-6H,(H,7,8)(H,9,10)/t9-;1-,2-/m01/s1
InChI key
QULBVRZTKPQGCR-NDAAPVSOSA-N
Gene Information
human ... DRD2(1813)
Powiązane kategorie
1 of 4
Ta pozycja | |||
|---|---|---|---|
| form solid | form powder | form solid | form solid |
| assay >97% | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| solubility H2O: 89 mg/mL | solubility H2O: soluble >10 mg/mL, ethanol: soluble 2.6 mg/mL, 0.1 M HCl: soluble 7 mg/mL | solubility H2O: 10 mg/mL | solubility H2O: 13 mg/mL |
| color white | color off-white | color white | color white |
| Gene Information human ... DRD2(1813) | Gene Information human ... DRD2(1813) | Gene Information - | Gene Information human ... OPRK1(4986) |
Application
S(−)-Raclopride (+)-tartrate salt has been used as a D2 receptor antagonist:
- to study the role of the D2 receptor in mediating ventrolateral PAG (vlPAG)/dorsal raphe dopaminergic antinociceptive effect in animals
- in pharmacological and behavioral studies performed with Thap1 null mice
- to determine the relationship between Ca2+ transients and dopamine neuron activity in rats
Biochem/physiol Actions
Raclopride is a benzamide derivative and a selective D2 dopamine receptor antagonist.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Disclaimer
Photosensitive
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
H Lublin et al.
Psychopharmacology, 112(2-3), 389-397 (1993-01-01)
The effects of chronic treatment with dopamine (DA) D1 and D2 receptor antagonists were evaluated in eight cebus apella monkeys with mild oral dyskinesia after previous haloperidol treatment. SCH 23390 (D1 antagonist) was given daily to investigate the direct behavioural
Angel Toval et al.
Molecular neurobiology, 58(4), 1782-1791 (2021-01-05)
Improving exercise capacity during adolescence impacts positively on cognitive and motor functions. However, the neural mechanisms contributing to enhance physical performance during this sensitive period remain poorly understood. Such knowledge could help to optimize exercise programs and promote a healthy
P Protais et al.
European journal of pharmacology, 271(1), 167-177 (1994-12-12)
S 14506 (1-[-(4-fluorobenzoylamino)ethyl]-4-(7-methoxynaphthyl)piper azine hydrochloride), 8-OH-DPAT ((+/-)-8-hydroxydipropylaminotetralin hydrobromide), clozapine and raclopride were compared in some behavioural models able to characterize dopamine antagonist properties. In mice treated with apomorphine (0.75 mg/kg, s.c.), stereotyped climbing and sniffing were dose dependently antagonized by
J Kopp et al.
Neuroscience, 47(4), 771-779 (1992-01-01)
Prolonged treatment with dopamine D2 receptor antagonists is known to elevate the density of dopamine D2 receptor binding sites in caudate-putamen and nucleus accumbens in rat and human brain. In this study we used the dopamine D2 receptor antagonist raclopride
Vaibhav R Konanur et al.
Physiology & behavior, 215, 112771-112771 (2019-12-11)
Phasic dopamine activity is evoked by reliable predictors of food reward and plays a role in cue-triggered, goal-directed behavior. While this important signal is modulated by physiological state (e.g. hunger, satiety), the mechanisms by which physiological state is integrated by
Powiązane treści
Datasheet
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| R121-100MG | 04061832093147 |
| R121-25MG | 04061836694272 |
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If a stock solution of raclopride tartrate is made in PBS, can this be stored aliquoted in -20°C? If so, for how long can this be stored?
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