P4056

Platelet-Derived Growth Factor-BB from rat

Name: Platelet-Derived Growth Factor-BB from rat
Brand: SIGMA
Price: 1840 PLN

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonim(y):

PDGF-BB

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P4056-50UG

1840,00 zł

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Informacje o tej pozycji

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD01094933

Biological source:

rat

Recombinant:

expressed in E. coli

Assay:

≥97% (SDS-PAGE)

Form:

lyophilized powder

Mol wt:

~30 kDa

Impurities:

≤1 EU/μg

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Nazwa produktu

Platelet-Derived Growth Factor-BB from rat, PDGF-BB, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

rat

Quality Level

100

recombinant

expressed in E. coli

assay

≥97% (SDS-PAGE)

form

lyophilized powder

potency

1.62 ng/mL EC₅₀

quality

endotoxin tested

mol wt

~30 kDa

packaging

pkg of 5x50 μg, pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

≤1 EU/μg

UniProt accession no.

P31240

storage temp.

−20°C

Gene Information

rat ... Pdgfb(24628)

Powiązane kategorie

Cell Culture & Analysis

Cell Culture Supplements & Reagents

Growth Factors and Cytokines

Molecular Biology & Functional Genomics

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Ta pozycja	P4306	P3201	P3326
Sigma-Aldrich P4056 Platelet-Derived Growth Factor-BB from rat	P4306 Platelet-Derived Growth Factor-BB human	P3201 Platelet-Derived Growth Factor-BB human	Sigma-Aldrich P3326 Platelet-Derived Growth Factor-AB human
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 200
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder
packaging pkg of 5x50 μg, pkg of 50 μg	packaging pkg of 10 μg	packaging pkg of 10 μg, pkg of 50 μg	packaging pkg of 10 μg, pkg of 50 μg
Gene Information rat ... Pdgfb(24628)	Gene Information human ... PDGFB(5155)	Gene Information human ... PDGFB(5155)	Gene Information human ... PDGFA(5154), PDGFB(5155)

General description

Platelet-derived growth factor (PDGF) is a 30 kDa cationic polypeptide and consists of two disulphide linked chains A and B. PDGF is expressed as hetero and homodimers : PDGF-AB FDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD.

Application

Platelet-Derived Growth Factor-BB from rat has been used as a growth supplement in mouse embryonic fibroblast culture, motoneuron-muscle co-culture and adult spinal cord neurons culture.

Biochem/physiol Actions

Platelet-derived growth factor (PDGF) elicits multifunctional actions with a variety of cells. It is mitogenic to mesoderm-derived cells, such as dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells, and chondrocytes. PDGF is a potent chemoattractant and activator of neutrophils, monocytes, and fibroblasts.[1] PDGF activates smooth muscle relocalization and multiplication. PDGF mediated increased smooth muscle muscle proliferation might be associated with gene regulation. It increases the synthesis of phospholipids, cholesterol esters, glycogen and prostaglandins, and modulates LDL (low density lipoprotein) receptor binding.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 2.5 mg bovine serum albumin.

Analysis Note

The biological activity is measured by its ability to stimulate ³H-thymidine incorporation in quiescent NR6R-3T3 fibroblasts.

Other Notes

Dimer of the B chain of rat PDGF.

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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Skeletal muscle tissue engineering: A maturation model promoting long-term survival of myotubes, structural development of the excitation?contraction coupling apparatus and neonatal myosin heavy chain expression.

Das M, et al.

Biomaterials, 30.29, 5392-5402 (2009)

Role of platelets in the development of atherosclerosis.

Quintana L, et al.

Tissue Engineering: Part A, 15.1, 45-54 (2008)

AktAR and Akt-STOPS: Genetically Encodable Molecular Tools to Visualize and Perturb Akt Kinase Activity at Different Subcellular Locations in Living Cells.

Xin Zhou et al.

Current protocols, 2(5), e416-e416 (2022-05-10)

The serine/threonine protein kinase Akt integrates diverse upstream inputs to regulate cell survival, growth, metabolism, migration, and differentiation. Mounting evidence suggests that Akt activity is differentially regulated depending on its subcellular location, which can include the plasma membrane, endomembrane, and

Platelet-Derived Growth Factor?BB Transactivates the Fibroblast Growth Factor Receptor to Induce Proliferation in Human Smooth Muscle Cells.

Millette E, et al.

Trends in Cardiovascular Medicine, 16.1, 25-28 (2006)

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