P1999

PEAQX tetrasodium hydrate

Name: PEAQX tetrasodium hydrate
Brand: SIGMA
Price: 789.65 PLN

≥98% (HPLC)

Synonim(y):

NVP-AAM077 tetrasodium hydrate, [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium hydrate

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5 MG

789,65 zł

25 MG

3250,00 zł

789,65 zł

Cena katalogowa929,00 złZaoszczędź 15%

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₇H₁₃BrN₃Na₄O₅P · xH₂O

Numer CAS:

459836-30-7

Masa cząsteczkowa:

542.14 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

329820113

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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SMILES string

[Na+].[Na+].[Na+].[Na+].[H]O[H].C[C@H](NC(c1cccc2nc([O-])c([O-])nc12)P([O-])([O-])=O)c3ccc(Br)cc3

InChI

1S/C17H17BrN3O5P.4Na.H2O/c1-9(10-5-7-11(18)8-6-10)19-17(27(24,25)26)12-3-2-4-13-14(12)21-16(23)15(22)20-13;;;;;/h2-9,17,19H,1H3,(H,20,22)(H,21,23)(H2,24,25,26);;;;;1H2/q;4*+1;/p-4/t9-,17?;;;;;/m0...../s1

InChI key

SMGAGBKXHAHCGQ-VSYRWHDMSA-J

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

water: 10 mg/mL

storage temp.

−20°C

Quality Level

100

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Ta pozycja	N183	A2979	SML2774
Sigma-Aldrich P1999 PEAQX tetrasodium hydrate	Sigma-Aldrich N183 NBQX disodium salt hydrate	Sigma-Aldrich A2979 A-317491 sodium salt hydrate	Sigma-Aldrich SML2774 KDOAM25 hydrochloride hydrate
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form lyophilized powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. -	storage temp. −20°C
solubility water: 10 mg/mL	solubility H₂O: >10 mg/mL	solubility H₂O: 15 mg/mL, clear	solubility H₂O: 2 mg/mL, clear
storage condition desiccated	storage condition desiccated	storage condition -	storage condition desiccated

Application

PEAQX tetrasodium hydrate has been used N-methyl-D-aspartate (NMDA) receptor 2A (NR2A) antagonist in rats[1][2] and mice.[3]

Biochem/physiol Actions

NMDA receptor antagonist.

PEAQX is more specific for N-methyl-D-aspartate (NMDA) receptor 2A (NR2A) than N-methyl-D-aspartate (NMDA) receptor 2B (NR2B) and induces striatal apoptosis. It is less potent in activating caspase-3 than its stereomer NVP-AAM007.[4]

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Lot/Batch Number

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits.

N C Anastasio et al.

Neuroscience, 163(4), 1181-1191 (2009-08-06)

The mechanism underlying phencyclidine (PCP)-induced apoptosis in perinatal rats and the development of schizophrenia-like behaviors is incompletely understood. We used antagonists for N-methyl-D-aspartate (NMDA) receptor subunit NR2A- and NR2B-containing NMDA receptor to test the hypothesis that the behavioral and apoptotic

The effects of an acute challenge with the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, on social inhibition in adolescent and adult male rats.

Melissa Morales et al.

Psychopharmacology, 231(8), 1797-1807 (2013-09-18)

NMDA antagonists consistently produce social inhibition in adult animals, although effects of these manipulations on social behavior of adolescents are relatively unknown. The aim of this study was to assess potential age differences in the socially inhibitory effects of the

5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition.

Yves P Auberson et al.

Bioorganic & medicinal chemistry letters, 12(7), 1099-1102 (2002-03-23)

NMDA antagonists derived from 5-phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione (3a) are potent anticonvulsant agents, and display strong protective effects in the electroshock-induced convulsion assay in mice. Their preference for the human NMDAR 1A/2A over 1A/2B subunit composition was optimized, leading to (1RS,1'S)-PEAQX (9r), which

Manipulation of hippocampal CA3 firing via luminopsins modulates spatial and episodic short-term memory, especially working memory, but not long-term memory.

Da Song et al.

Neurobiology of learning and memory, 155, 435-445 (2018-09-24)

The CA3 subregion of the hippocampus is important for rapid encoding, storage and retrieval of associative memories. Lesions and pharmacological inhibitions of hippocampal CA3 suggest that it is essential for different memories. However, how CA3 functions in spatial and episodic

Low doses of the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, induces social facilitation in adolescent male rats.

Melissa Morales et al.

Behavioural brain research, 250, 18-22 (2013-05-09)

Adolescents display high levels of interactions with peers relative to other age groups, with these interactions further enhanced by ethanol under some circumstances. Understanding of the neural mechanisms underlying these high levels of social interactions is important given that alcohol

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PEAQX tetrasodium hydrate

≥98% (HPLC)

Wybierz wielkość

P1999-5MG

789,65 zł

Informacje o tej pozycji

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Właściwości

SMILES string

InChI

InChI key

assay

form

storage condition

color

solubility

storage temp.

Quality Level

Porównaj podobne pozycje

Ta pozycja

Opis

Application

Biochem/physiol Actions

Features and Benefits

Informacja o środkach bezpieczeństwa

pictograms

signalword

hcodes

pcodes

Hazard Classifications

target_organs

Klasa składowania

wgk

flash_point_f

flash_point_c

ppe

Dokumentacja

Certyfikaty analizy (CoA)

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