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M1949
S-methyl-5′-thioadenosine phosphorylase human
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Informacje o tej pozycji
recombinant
expressed in E. coli
Quality Segment
assay
≥80% (SDS-PAGE)
form
solution
relevant disease(s)
cancer
shipped in
dry ice
storage temp.
−70°C
General description
N-terminal GST-tagged 57 kDa protein containing amino acids 2-end.
Application
S-methyl-5′-thioadenosine phosphorylase human (MTAP) is an enzyme used in cancer research that is deficient in many types of cancer. Decreased MTAP expression may be used as a potential indicator of disease progression of gastrointestinal stromal tumors [1]. MTAP may be a used to develop potential therapeutic strategies for hepatocellular carcinoma (HCC) since MTAP inactivation has been linked to HCC development and invasiveness .
Biochem/physiol Actions
MTAP expression is crucial for the catabolism of methylthioadenosine, which is a by-product of polyamine biosynthesis in the methionine salvage pathway. Protein expression is decreased by homozygous deletion and promoter hypermethylation [1].
Physical form
Supplied as a solution in 25 mM Tris-HCl, pH 8.0,100 mM NaCl, 0.05% Tween®-20, 10% glycerol,and 3 mM DTT.
Legal Information
TWEEN is a registered trademark of Croda International PLC
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Ta pozycja | |||
|---|---|---|---|
| assay ≥80% (SDS-PAGE) | assay ≥80% (SDS-PAGE) | assay ≥80% (SDS-PAGE) | assay ≥80% (SDS-PAGE) |
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli |
| form solution | form aqueous solution | form aqueous solution | form aqueous solution |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
| Quality Level 200 | Quality Level - | Quality Level - | Quality Level - |
Klasa składowania
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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